Sandbox Reserved 1120
From Proteopedia
(Difference between revisions)
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<StructureSection load='1hry' size='340' side='right' caption='The SRY protein linked to DNA' scene=''> | <StructureSection load='1hry' size='340' side='right' caption='The SRY protein linked to DNA' scene=''> | ||
| - | The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance (MIS gene) | + | The SRY protein is a monomeric 203 residues long polypeptide. It is a '''transcriptionnal factor''', more precisely a transcriptionnal activator of the '''M'''üllerian '''In'''hibiting '''S'''ubstance ('''MIS''' gene). |
It is encoded by the human testis-determining sex gene. | It is encoded by the human testis-determining sex gene. | ||
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===The hSRY-HMG domain=== | ===The hSRY-HMG domain=== | ||
| + | '''SRY-HMG''' stands for '''S'''ex determining '''R'''egion '''Y''' - '''H'''igh '''M'''obility '''D'''omain | ||
It is a approximately 80residues domain.. It mediates minor groove DNA binding proteins. | It is a approximately 80residues domain.. It mediates minor groove DNA binding proteins. | ||
Twisted L shape : Concave surface. 3 helices & N and C end strands. | Twisted L shape : Concave surface. 3 helices & N and C end strands. | ||
Binds the DNA by its minor groove. | Binds the DNA by its minor groove. | ||
| - | + | 2 kinds of HMG domain: | |
| + | * HMG1 | ||
| + | * HMG2 | ||
===General structure of SRY=== | ===General structure of SRY=== | ||
3 domains: | 3 domains: | ||
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===Sex determining=== | ===Sex determining=== | ||
* MSI | * MSI | ||
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| - | C'est une protéine de l'ambiance. Elle peut tout faire. | ||
==Implication== | ==Implication== | ||
== Disease == | == Disease == | ||
| - | |||
| - | C'est une protéine de l'ambiance. Elle ne cause aucune maladie | ||
== Relevance == | == Relevance == | ||
Revision as of 19:41, 30 December 2015
| This Sandbox is Reserved from 15/12/2015, through 15/06/2016 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1120 through Sandbox Reserved 1159. |
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SRY protein (AKA TDF protein)
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