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Adrenergic receptor

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* [[Beta-2 Adrenergic Receptor]]<br />
* [[Beta-2 Adrenergic Receptor]]<br />
* [[G protein-coupled receptor]]<br />
* [[G protein-coupled receptor]]<br />
 +
* [[Beta2 adregenic receptor-Gs protein complex]]<br />
* [[Neurodevelopmental Disorders]].
* [[Neurodevelopmental Disorders]].
<scene name='Adrenergic_receptor/Cv/1'>Click here to see transition from active to inactive conformation of alpha adrenergic receptor</scene> (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]).
<scene name='Adrenergic_receptor/Cv/1'>Click here to see transition from active to inactive conformation of alpha adrenergic receptor</scene> (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]).

Revision as of 10:53, 28 January 2016

Crystal Structure of β-2 Adrenergic Receptor, 2rh1
Crystal Structure of β-2 Adrenergic Receptor, 2rh1

Template:STRUCTURE 2r4r













The adrenergic receptors are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response.

  • The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release.
  • The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin.[1]
  • The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions.

See also

(morph was taken from Gallery of Morphs of the Yale Morph Server).

 

β2 adrenergic receptor binding a hormone analog
and complexed to a heterotrimeric G protein (3sn6)

 

Drag the structure with the mouse to rotate
An activated G protein-coupled receptor (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) (3sn6), resolution 3.2Å. The boundaries of the membrane in which the GPCR sits are represented in light green.



This is the first structure of an activated GPCR in a complex with its G protein.
See also The Madison West High School 2008 SMART Team's Page on the β-2 adrenergic receptor

Contents

Nobel Prize Related to the Structures

Robert J. Lefkowitz and Brian K. Kobilka share the 2012 Nobel Prize in Chemistry for work on GPCRs that includes solving the first structures of a ligand-activated GPCR (2r4r, 2r4s, & 2rh1 in 2007)[1][2][3] and the first activated GPCR in complex with its G protein (3sn6 in 2011)[4][5][6][7]. A detailed description of the laureates' body of work on this class of receptors with images is here.









3D Structures of Adrenergic receptor

Updated on 28-January-2016

References

  1. ↑ Huang J, Chen S, Zhang JJ, Huang XY. Crystal structure of oligomeric beta1-adrenergic G protein-coupled receptors in ligand-free basal state. Nat Struct Mol Biol. 2013 Apr;20(4):419-25. doi: 10.1038/nsmb.2504. Epub 2013 Feb, 24. PMID:23435379 doi:10.1038/nsmb.2504

See Also

External Resources

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