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4. Base catalysis by enzyme; H2O forms a covalent bond with the carbonyl group of the N-terminal peptide, leading to another tetrahedral intermediate | 4. Base catalysis by enzyme; H2O forms a covalent bond with the carbonyl group of the N-terminal peptide, leading to another tetrahedral intermediate | ||
5. Acid catalysis by the breaking of the C-O covalent bond of the tetrahedral intermediate, releasing the peptide from the enzyme substrate complex. Once the peptide is released, the enzyme once again becomes active. <ref>PMID:16636277</ref>. | 5. Acid catalysis by the breaking of the C-O covalent bond of the tetrahedral intermediate, releasing the peptide from the enzyme substrate complex. Once the peptide is released, the enzyme once again becomes active. <ref>PMID:16636277</ref>. | ||
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| + | Serine 195 - Base Catalysis Residue | ||
| + | Histidine 57 - Acid Catalysis Residue | ||
| + | Aspartic Acid 102 - Important Residue in Stabilization of Catalytic Mechanism | ||
== Disease == | == Disease == | ||
Revision as of 03:39, 15 February 2016
Trypsin Structure
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