User:Gisselle Medina/Sandbox7 Leader
From Proteopedia
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<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' /> | <Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' /> | ||
==Structure== | ==Structure== | ||
| - | The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. | + | The <scene name='48/484916/Starting_molecule/3'>leader protein (Lpro</scene> from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. |
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right. | Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right. | ||
Revision as of 17:18, 28 February 2016
Introduction
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Structure
The from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage.This self-processing event is believed to occurred intramolecularly due to the presence of a flexible CTE is composed of 18 amino acid residues and presumably can fold back into its own . Lbpro contains an domain on the left and a predominantly domain on the right.
