User:Gisselle Medina/Sandbox7 Leader
From Proteopedia
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==Introduction== | ==Introduction== | ||
<Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' /> | <Structure load='2JQG' size='450' frame='true' align='right' caption='FMDV Lbpro' scene='Insert optional scene name here' /> | ||
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| + | <scene name='48/484916/Starting_molecule/4'>TextToBeDisplayed</scene> | ||
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==Structure== | ==Structure== | ||
The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart. | The <scene name='48/484916/Starting_molecule/3'>leader protein</scene> (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible <scene name='User:Gisselle_Medina/Sandbox7_Leader/C_terminal_extension/2'>C-terminal extension</scene> CTE is composed of 18 amino acid residues and presumably can fold back into its own <scene name='User:Gisselle_Medina/Sandbox7_Leader/Active_site_mutated/1'>active site</scene>. Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart. | ||
Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right. | Lbpro contains an <scene name='48/484916/Alpha_helix/1'>α-helical</scene> domain on the left and a predominantly <scene name='48/484916/Beta_sheet/1'>β-sheet</scene> domain on the right. | ||
Revision as of 14:07, 29 February 2016
Introduction
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Structure
The (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible CTE is composed of 18 amino acid residues and presumably can fold back into its own . Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart. Lbpro contains an domain on the left and a predominantly domain on the right.
