User:Gisselle Medina/Sandbox7 Leader

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Leader is a papain-like cysteine protease that functions as a virulent factor during replication of foot-and-mouth disease virus (FMDV).

Structure

Structure

The (Lpro)from FMDV is a cysteine protease and constitutes a virulent factor during FMDV infection. It is the first protein that is translated from the growing polyprotein and upon translation frees itself by self cleavage. This self-processing event is believed to occurred intramolecularly due to the presence of a flexible CTE is composed of 18 amino acid residues and presumably can fold back into its own . Lpro is produced in two forms, named Lab and Lb, due to the initiation of protein synthesis at two AUG located 84 nucleotides apart. Lbpro contains an domain on the left and a predominantly domain on the right.