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Introduction

Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA1) is a G-protein coupled receptor(link) and one of 6 different LPA receptors (LPA1-LPA6) that bind the phospholipid derivative lysophosphatidic acid (LPA)-link?, a signaling molecule that acts as a potent mitogen upon binding to one of the six receptors. LPA is present in nearly all cells and tissues throughout the body, and deletion of the LPA1 receptor has shown to have physiological effects on every organ system. ----------- LPA1 is part of the larger EDG receptor family(link) which includes the more widely known sphingosine 1-phopshate receptors.

Structure

Key Ligand Interactions

Function

Disease Relevance

Receptor Comparison

Sphingosine 1-Phosphate Receptor

Endocannabinoid Receptor 1

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