Sandbox Reserved 1172

Introduction

Lysophosphatidic Acid Receptor 1 (commonly referred to as LPA1) is a G-protein coupled receptor(link) and one of 6 different LPA receptors (LPA1-LPA6) that bind the phospholipid derivative lysophosphatidic acid (LPA)-link?, a signaling molecule that acts as a potent mitogen upon binding to one of the six receptors. Specifically, the LPA1 receptor has been found to initiate downstream signaling cascades with three Galpha(link) proteins that signal for cell proliferation, survival, and migration. Because of the signaling activity of LPA1, abnormal expression has been linked to tumor growth, survival, and migration. The LPA1 receptor is present in nearly all cells and tissues throughout the body, and deletion of the LPA1 receptor has been found to have physiological effects on every organ system. Despite this receptor being expressed throughout the body, LPA1 has been found to be expressed highly in neural tissue, aiding in Schwann cell migration and myelination, formation of synapses, and glial cell growth. ----------- LPA1 is part of the larger EDG receptor family(link) which includes the more widely known sphingosine 1-phopshate receptors.

Structure

Key Ligand Interactions

Function

Disease Relevance

Receptor Comparison

Sphingosine 1-Phosphate Receptor

Endocannabinoid Receptor 1

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