From Proteopedia
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| | == Neurotensin == | | == Neurotensin == |
| | == Structure == | | == Structure == |
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| | === Overall Structure === | | === Overall Structure === |
| | + | [[Image:Image of structure of G protein coupled receptor.jpg |100 px|left|thumb|G protein across membrane ]] |
| | === Neurotensin Binding Site === | | === Neurotensin Binding Site === |
| | === Hydrophobic Stacking === | | === Hydrophobic Stacking === |
Revision as of 19:09, 28 March 2016
Neurotensin Receptor (Rattus norvegicus)
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Introduction
The neurotensin receptor (NTSR1) belongs to the superfamily of proteins known as G protein-coupled receptors(link to g protein page in proteopedia) and responds to the 13 amino acid hormone nuerotensin (NT). There are currently around 800 G protein-coupled receptors that have been identified and they are thought to be responsible for roughly 80% of signal transduction across the cell membrane.(reference (year in g protein) These receptors are involved in a vast array of physiological processes within the body and are a major site of drug targets in medicine. (reference 5 main families)
Neurotensin
Structure
Overall Structure
Neurotensin Binding Site
Hydrophobic Stacking
Sodium Binding Pocket
Allosteric Effects
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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References
Millar, Robert P., and Claire L. Newton. "The year in G protein-coupled receptor research." Molecular endocrinology 24.1 (2010): 261-274.
Fredriksson, Robert, et al. "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints." Molecular pharmacology 63.6 (2003): 1256-1272.
