Sandbox reserved 1169
From Proteopedia
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== Structure == | == Structure == | ||
=== Overall Structure === | === Overall Structure === | ||
| - | Like other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein, a region containing 7 transmembrane alpha helices that transduce the signal from the extracellular side of the cell membrane to the intracellular side, and an intracellular region that when activated by a conformational change in the protein activates a [https://en.wikipedia.org/wiki/G_protein G protein] associated with this receptor. | + | Like other G protein-coupled receptors, the neurotensin receptor is composed of 3 distinct regions. An extracellular binding site where neurotensin binds and causes a conformational change of the protein, a region containing <scene name='72/727765/Overall_structure/1'>7 transmembrane alpha helices</scene> that transduce the signal from the extracellular side of the cell membrane to the intracellular side, and an intracellular region that when activated by a conformational change in the protein activates a [https://en.wikipedia.org/wiki/G_protein G protein] associated with this receptor. |
[[Image:Image of structure of G protein coupled receptor.jpg |100 px|left|thumb|G protein across membrane ]] | [[Image:Image of structure of G protein coupled receptor.jpg |100 px|left|thumb|G protein across membrane ]] | ||
=== Neurotensin Binding Site === | === Neurotensin Binding Site === | ||
Revision as of 23:38, 28 March 2016
Neurotensin Receptor (Rattus norvegicus)
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References
Millar, Robert P., and Claire L. Newton. "The year in G protein-coupled receptor research." Molecular endocrinology 24.1 (2010): 261-274.
Fredriksson, Robert, et al. "The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints." Molecular pharmacology 63.6 (2003): 1256-1272.
