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Introduction

Human GPR40 receptor, hGPR40, is a free fatty-acid receptor that binds to long chain free fatty acids, inducing insulin secretion. However, what makes this receptor significant is that the secretion of insulin is glucose dependent. Thus, there needs to be an agonist bound, in addition to presence of glucose in the blood in order for insulin secretion to occur. This glucose-dependence makes GPR40 a target for type-2 diabetes because it allows for increased glycemic control and therefore, low risk of hypoglycemia.

Structure

Figure Legend

Transmembrane Proteins

Extracellular Loops

Disulfide Bond

Figure Legend

Function

Disease

Relevance

Structural highlights

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