Methyl CpG binding protein
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | Thymine from the mismatched G:T pair flips out from the DNA strand and interchelates with MBD4 residues Lys and Leu<ref>PMID:22740654</ref>. | + | <scene name='59/597003/Cv/2'>Thymine from the mismatched G:T pair flips out from the DNA strand and interchelates with MBD4 residues Lys and Leu</scene><ref>PMID:22740654</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 08:45, 15 May 2016
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3D structures of methyl CpG binding protein
Updated on 15-May-2016
References
- ↑ Wade PA. Methyl CpG-binding proteins and transcriptional repression. Bioessays. 2001 Dec;23(12):1131-7. PMID:11746232 doi:http://dx.doi.org/10.1002/bies.10008
- ↑ Van den Veyver IB, Zoghbi HY. Mutations in the gene encoding methyl-CpG-binding protein 2 cause Rett syndrome. Brain Dev. 2001 Dec;23 Suppl 1:S147-51. PMID:11738862
- ↑ Hashimoto H, Zhang X, Cheng X. Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation. Nucleic Acids Res. 2012 Jun 27. PMID:22740654 doi:10.1093/nar/gks628
