1k3v
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= VP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10796 Porcine parvovirus]) | |GENE= VP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10796 Porcine parvovirus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[4dpv|4dpv]], [[1fpv|1fpv]], [[1mvm|1mvm]], [[1dnv|1dnv]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k3v OCA], [http://www.ebi.ac.uk/pdbsum/1k3v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1k3v RCSB]</span> | ||
}} | }} | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:43:04 2008'' |
Revision as of 18:43, 30 March 2008
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| , resolution 3.5Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | VP2 (Porcine parvovirus) | ||||||
| Related: | 4dpv, 1fpv, 1mvm, 1dnv
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Porcine Parvovirus Capsid
Overview
The structure of baculovirus-expressed porcine parvovirus (PPV) capsids was solved using X-ray crystallography and was found to be similar to the related canine parvovirus (CPV) and minute virus of mice (MVM). The PPV capsid protein has 57 % and 49 % amino acid sequence identity with CPV and MVM, respectively, but the degree of conservation of surface-exposed residues is lower than average. Consequently, most of the structural differences are on the surface and are the probable cause of the known variability in antigenicity and host range. The NADL-2 and Kresse strains of PPV have distinct tissue tropisms and pathogenicity, which are mediated by one or more of the amino acid residues 381, 386, and 436. These residues are on or near the surface of the virus capsid, where they are likely to be associated with virus-cell interactions.
About this Structure
1K3V is a Single protein structure of sequence from Porcine parvovirus. Full crystallographic information is available from OCA.
Reference
The structure of porcine parvovirus: comparison with related viruses., Simpson AA, Hebert B, Sullivan GM, Parrish CR, Zadori Z, Tijssen P, Rossmann MG, J Mol Biol. 2002 Feb 1;315(5):1189-98. PMID:11827486
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