Rhomboid protease
From Proteopedia
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<StructureSection load='4h1d' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor DFP (PDB entry [[4h1d]])' scene=''> | <StructureSection load='4h1d' size='350' side='right' caption='Structure of rhomboid protease complex with inhibitor DFP (PDB entry [[4h1d]])' scene=''> | ||
| - | + | == Function == | |
| - | '''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. | + | '''Rhomboid protease''' is a transmembranal serine protease. The active site is buried in the lipid bilayer of cell membrane. It cleaves proteins within their transmembrane domain<ref>PMID:18605900</ref>. Rhomboids regulate many cellular processes and are involved in many human diseases. The catalytic site of rhomboids contains a hydrophilic pocket protected by from the lipid bilayer. Rhomboids are specific for a single transmembranal helix proteins. |
</StructureSection> | </StructureSection> | ||
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| + | == References == | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 06:34, 10 August 2016
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3D Structures of rhomboid protease
Updated on 10-August-2016
References
- ↑ Freeman M. Rhomboid proteases and their biological functions. Annu Rev Genet. 2008;42:191-210. doi: 10.1146/annurev.genet.42.110807.091628. PMID:18605900 doi:http://dx.doi.org/10.1146/annurev.genet.42.110807.091628
