OBrochtasSandbox

(Difference between revisions)

Revision as of 18:06, 16 January 2017

==O'Brochta's Sandbox == 0

The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'

This shows the basic structure of the kinase domain with an . The ATP will sit between them just below Beta 1

shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a .

These are found in other RTKs.

G1000S (magenta), A1133G (orange), T1221I (teal)

And as a

This when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster

@@ Line 15: / Line 15: @@
 And as a <scene name='75/750300/Geneticmutationsspacefilled/1'>spacefilled model</scene>
-<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
+This <scene name='75/750300/T1221_spacefilled/1'>threonine</scene> when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster