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OBrochtasSandbox
From Proteopedia
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==O'Brochta's Sandbox == 0 | ==O'Brochta's Sandbox == 0 | ||
| - | <StructureSection load='Model.itasser.relax.pdb' size='800' side='right' caption='Anopheles arabiensis InR kinase domain model' scene=' | + | <StructureSection load='Model.itasser.relax.pdb' size='800' side='right' caption='Anopheles arabiensis InR kinase domain model' scene='75/750300/Kinase_n_and_c_lobes/1' /> |
The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project' | The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project' | ||
Revision as of 18:09, 16 January 2017
==O'Brochta's Sandbox == 0
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The Anopheles arabiensis Insulin Receptor's kinase domain was modeled by Brian Pierce for the 'An arab ts lethal project'
This shows the basic structure of the kinase domain with an . The ATP will sit between them just below Beta 1
shows the ATP binding site (purple) and the catalytic loop (green). Here it is as a .
These are found in other RTKs.
G1000S (magenta), A1133G (orange), T1221I (teal)
And as a
This when mutated to isoleucine resulted in ts lethal mutations in the sevenless and EGFR-like genes in D. melanogster
