Rac GTPase-activating protein

From Proteopedia

---

Revision as of 09:07, 12 February 2017

proteopedia linkproteopedia link

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Rac GTPase-activating protein 1 (RACGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis. It is involved in the regulation of growth-related processes in adipocytes and myoblasts. Disease Relevance RACGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma[1]. Structural highlights

3D structures of Rac GTPase-activating protein 1

Updated on 12-February-2017

• • 3w6r, 2ovj – hRacGAP GAP domain – human
    
  • 3wpq, 3wps – hRacGAP GAP domain (mutant)
    
  • 4b6d – hRacGAP C1 domain
    
  • 5c2j – hRacGAP GAP domain + CDC42 + GDP
    

References

1. ↑ Wang SM, Ooi LL, Hui KM. Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin Cancer Res. 2011 Sep 15;17(18):6040-51. doi: 10.1158/1078-0432.CCR-11-0557. , Epub 2011 Aug 8. PMID:21825042 doi:http://dx.doi.org/10.1158/1078-0432.CCR-11-0557