Rac GTPase-activating protein

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Revision as of 09:11, 12 February 2017

Human Rac GTPase-activating protein 1 GAP domain (grey) complex with CDC42 (green) and GDP (PDB code 5c2j)

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Updated on 12-February-2017

- 3w6r, 2ovj – hRacGAP GAP domain – human
- 3wpq, 3wps – hRacGAP GAP domain (mutant)
- 4b6d – hRacGAP C1 domain
- 5c2j – hRacGAP GAP domain + CDC42 + GDP

↑ Wang SM, Ooi LL, Hui KM. Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin Cancer Res. 2011 Sep 15;17(18):6040-51. doi: 10.1158/1078-0432.CCR-11-0557. , Epub 2011 Aug 8. PMID:21825042 doi:http://dx.doi.org/10.1158/1078-0432.CCR-11-0557

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+<StructureSection load='5c2j' size='340' side='right' caption='Human Rac GTPase-activating protein 1 GAP domain (grey) complex with CDC42 (green) and GDP (PDB code [[5c2j]])' scene=''>
-<StructureSection load='5c2j' size='340' side='right' caption='Caption for this structure' scene=''>
 == Function ==
-'''Rac GTPase-activating protein 1''' (RACGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis.  It is involved in the regulation of growth-related processes in adipocytes and myoblasts.
+'''Rac GTPase-activating protein 1''' (RacGAP1) is required for the attachment of the midbody to the cell membrane during cytokinesis.  It is involved in the regulation of growth-related processes in adipocytes and myoblasts.
-== Disease ==
 == Relevance ==
-RACGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma<ref>PMID:21825042</ref>.
+RacGAP1 expression is a prognostic marker for HBV-positive human hepatocellular carcinoma and can be a potential molecular target for therapeutic strategies against this carcinoma<ref>PMID:21825042</ref>.
-== Structural highlights ==