Sandbox Reserved 1235

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== '''Antifreeze protein 1''' ==
== '''Antifreeze protein 1''' ==
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<scene name='75/750284/Antifreeze_protein1_wntr_flndr/1'>Normal state</scene>
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[[Image:Anti_freeze_protein_1_pciture_2.png]]
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[[Image:Anti_freeze_protein_1_pciture_2.png]]<ref>http://amazingbiotech.blogspot.com/2014/02/antifreeze-proteins.html </ref>
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Revision as of 17:05, 9 March 2017

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This Sandbox is Reserved from Jan 17 through June 31, 2017 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, USA. This reservation includes Sandbox Reserved 1225 through Sandbox Reserved 1244.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Antifreeze protein 1

Papers

as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.


Function

to constrain the process of recrystalization of water as Fishes swim to colder climates , for example like the winter flounder migrating to the northern pole. The molecule is found in many other fish as well that migrate to colder climates such as the shorthorn sculpin, and longhorn sculpin. . The function is to depress freezing temperature in order to stop the process of recrystallization to occur. recrystallization is When water begins to freeze, many small crystals form, but then a few small crystals dominate and grow larger and larger, stealing water molecules from the surrounding small crystals. Thus making it manageable for fishes like the winter flounder to swim in colder climates.

Image:Anti_freeze_protein_1_pciture_2.png[3]

Image:Anti_freeze_protein_1_pciture_3.png



Disease

Genetic disease

Mutations DNA Protein

Relevance

Structural highlights

Structure

This version of AFP could be recorded as the best documented, for it is the first to have three-dimensional structure determined. it is about 3.3 to 4.5 k Daltons in size. its structure consists of single, long, amphipathic alpha helix. The three dimensional structure consists of three faces: a hydrophobic face, a hydrophilic face, and a Thr-Asx face

PDB ID 4ke2

Drag the structure with the mouse to rotate

References

Picture 1: https://en.wikipedia.org/wiki/Antifreeze_protein Picture 2: http://amazingbiotech.blogspot.com/2014/02/antifreeze-proteins.html Picture 3: http://2011.igem.org/Team:KULeuven/Afp

https://www.ncbi.nlm.nih.gov/pubmed/11181960 https://pdb101.rcsb.org/motm/120 http://www.fasebj.org/content/4/8/2460.short http://www.nature.com/nature/journal/v406/n6793/abs/406325a0.html

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. ↑ http://amazingbiotech.blogspot.com/2014/02/antifreeze-proteins.html
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