Molecular Playground/Insulin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 14: Line 14:
-
==3D structures of Insulin (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) ==
+
==3D structures of Insulin==
 +
(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}})
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
Line 20: Line 21:
* Insulin
* Insulin
-
** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]], [[2mli]], [[4p65]], [[4rxw]], [[2w44]], [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4xc4]] - hIns A chain + B chain – human <BR />
+
** [[3i3z]], [[3i40]], [[3e7y]], [[3e7z]], [[2qiu]], [[2c8q]], [[2c8r]], [[1q4v]], [[1os3]], [[1os4]], [[1mso]], [[1guj]], [[1g7a]], [[1g7b]], [[1xda]], [[1trz]], [[3zqr]], [[3zs2]], [[3zu1]], [[2lgb]], [[3v19]], [[3v1g]], [[4ajx]], [[4ajz]], [[4ak0]], [[4akj]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]], [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4fka]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[4gbn]], [[2m1d]], [[4iyd]], [[4iyf]], [[2mli]], [[4p65]], [[4rxw]], [[2w44]], [[3jsd]], [[2vjz]], [[2vk0]], [[1uz9]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[4xc4]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[5cny]], [[5bts]], [[5bqq]], [[5bpo]], [[5boq]] - hIns A chain + B chain – human <BR />
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR />
** [[1fu2]], [[1fub]] - hIns A chain + B chain – powder diffraction <BR />
-
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]] – hIns A chain + B chain (mutant) <BR />
+
** [[2kxk]], [[3bxq]], [[1b9e]], [[3rov]], [[3u4n]], [[4iuz]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[5hrq]], [[5hqi]], [[5hpu]], [[5hpr]], [[5ena]], [[5en9]] – hIns A chain + B chain (mutant) <BR />
-
** [[1zeh]], [[3zi3]] - hIns A chain (mutant) + B chain (mutant) <BR />
+
** [[1zeh]], [[3zi3]], [[5azz]] - hIns A chain (mutant) + B chain (mutant) <BR />
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
** [[3ir0]], [[3inc]], [[3ilg]], [[3kq6]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]] - hIns A chain + B chain + non-Zn metal ion<BR />
** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain <BR />
** [[3fq9]], [[1xw7]], [[1rwe]], [[1jca]], [[1j73]], [[4efx]] - hIns A chain (mutant) + B chain <BR />
** [[1w8p]], [[4cxl]], [[4cxn]], [[4cy7]], [[4nib]], [[4une]], [[4ung]], [[4unh]], [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]],[[ 2ws7]], [[1qj0]], [[3p2x]] - hIns A chain + B chain (mutant) <BR />
** [[1w8p]], [[4cxl]], [[4cxn]], [[4cy7]], [[4nib]], [[4une]], [[4ung]], [[4unh]], [[2wru]], [[2wrv]], [[2wrw]], [[2wrx]], [[2ws0]], [[2ws1]], [[2ws4]], [[2ws6]],[[ 2ws7]], [[1qj0]], [[3p2x]] - hIns A chain + B chain (mutant) <BR />
-
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]], [[3rto]], [[3fhp]] - pIns A chain + B chain – pig<BR />
+
** [[3gky]], [[2g4m]], [[1zni]], [[1znj]], [[1wav]], [[1iza]], [[1izb]], [[9ins]], [[4ins]], [[3ins]], [[3t2a]], [[4a7e]], [[3rto]], [[3fhp]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<BR />
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR />
** [[2zpp]], [[2efa]] - pIns A chain + B chain – Neutron <BR />
** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]], [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain + B chain – bovine <BR />
** [[2zp6]], [[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]], [[2a3g]], [[2bn1]], [[2bn3]] - bIns A chain + B chain – bovine <BR />
** [[3rto]], [[3fhp]] - pIns A chain + B chain <br />
** [[3rto]], [[3fhp]] - pIns A chain + B chain <br />
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
** [[1m5a]] - pIns A chain + B chain + non-Zn metal ion<BR />
-
** [[6ins]] – pIns single chain
+
** [[6ins]] – pIns single chain<br />
 +
**[[5jyq]] - Ins A chain + B chain – ''Conus geographus''<br />
* Insulin structures using NMR
* Insulin structures using NMR
Line 45: Line 47:
** [[1ho0]] - hIns B chain (mutant) – NMR<BR />
** [[1ho0]] - hIns B chain (mutant) – NMR<BR />
** [[2lwz]] – hIns single chain - NMR<br />
** [[2lwz]] – hIns single chain - NMR<br />
 +
**[[5miz]] - bIns A chain + B chain – NMR
* Insulin complexes
* Insulin complexes
Line 65: Line 68:
** [[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
** [[3w11]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br />
**[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br />
**[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br />
 +
**[[5mam]] - hIns A chain + B chain + serotonin <br />
 +
**[[5mt9]], [[5mt3]] - hIns A chain + B chain + serotonin + arginine<br />
** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
** [[1b17]], [[1b18]], [[1b19]], [[1b2a]], [[1b2b]], [[1b2c]], [[1b2d]], [[1b2e]], [[1b2f]], [[1b2g]] - pIns A chain + B chain + sulfate<BR />
** [[1mpj]] - pIns A chain + B chain + phenol<br />
** [[1mpj]] - pIns A chain + B chain + phenol<br />
Line 94: Line 99:
** [[1ju8]] – Lins A chain residues 1-37 – legume - NMR<BR />
** [[1ju8]] – Lins A chain residues 1-37 – legume - NMR<BR />
 +
 +
*Insulin lispro
 +
 +
**[[5udp]] – hIns – synthetic<br />
}}
}}

Revision as of 07:41, 19 June 2017

One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the Roberts Research Group and on display at the Molecular Playground.

Human insulin chain A (grey) and chain B (green), 3i40

Drag the structure with the mouse to rotate
For additional details see

Insulin Structure & Function
Diabetes & Hypoglycemia
Insulin (Hebrew)
Insulin mo-or-sl (Hebrew).


3D structures of Insulin

(Updated on 19-June-2017)

References

  1. ↑ Sonksen P, Sonksen J. Insulin: understanding its action in health and disease. Br J Anaesth. 2000 Jul;85(1):69-79. PMID:10927996
  2. ↑ Davidson HW. (Pro)Insulin processing: a historical perspective. Cell Biochem Biophys. 2004;40(3 Suppl):143-58. PMID:15289650
  3. ↑ Zakova L, Barth T, Jiracek J, Barthova J, Zorad S. Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain. Biochemistry. 2004 Mar 2;43(8):2323-31. PMID:14979729 doi:http://dx.doi.org/10.1021/bi036001w



Additional Resources

For additional information, see: Diabetes & Hypoglycemia

Retrieved from "http://52.214.119.220/wiki/index.php/Molecular_Playground/Insulin"
Personal tools