Function
Ribosomal protein L11 (RPL11) is one of the 34 proteins which belong to the large 50S subunit of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 23S RRNA from the large subunit[1]. In Archaea the protein is named L11P.
Relevance
Mutations in RPL11 are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients[2].
3D Structures of Ribosomal protein L11
Updated on 29-September-2017
2klm – TtRPL11 - Thermus thermophilus – SAXS
2e34 – TtRPL11 – RDC
2e35 – TtRPL11 – RG
2e36 – TtRPL11 – SANS
2h8w – TtRPL11 - NMR
5col – MjRPL11 - Methanocaldococcus jannaschii
5dar - MjRPL11 + RPL10 + 23S RRNA fragment
5d8h - MjRPL11 + RPL10 + 23S RRNA fragment + antibiotic
2nxn, 3cjq, 3cjt- TtRPL11 + L11 methyltransferase
3cjr, 3egv- TtRPL11 (mutant) + L11 methyltransferase
3cjs – TtRPL11 N-terminal+L11 methyltransferase N-terminal
1aci, 1foy, 1fow, 1fox, 2fow – GsRPL11 C-terminal – Geobacillus stearothermophilus – NMR
1y39, 1qa6, 1hc8 - GsRPL11 C-terminal+ 23S RRNA fragment
2k3f – TmRPL11 – Thermotoga maritima – NMR
1r2w, 1r2x, 1mms - TmRPL11 +23S RRNA fragment
2jq7 – TmRPL11+23S RRNA binding domain+thiostrepton – NMR
1oln - TmRPL11+23S RRNA binding domain+thiostrepton – Cryo-EM
1jqt – EcRPL11 – Cryo-EM - Escherichia coli
4xxb – RPL11 +Mdm2 - human
3ep2, 3eq3, 3eq4 – EcRPL11+RPS12+tRNA+16S RRNA fragments+23S RRNA fragments+EF-TU – Cryo-EM
2bcw – TmRPL11 N-terminal+EcRPL12 C-terminal +TtEF-G – Cryo-EM
1mj1 – EcRPL11+RPS12+RPS13+ 23S RRNA fragments+Phe-tRNA+EF-TU – Cryo-EM
1jqm, 1jqs - EcRPL11 +EF-G – Cryo-EM
3deg – EcRPL11+RPS12+A-site tRNA+P-site tRNA+16S RRNA fragments+23S RRNA fragments+GTP-binding protein LEPA – Cryo-EM
3j0d - EcRPL11+RPS12+16S RRNA fragments+23S RRNA fragments+ ribosome recycling factor – Cryo_EM
1c04 – HmRPL11P+RPL2+RPL6+RPL14+23S RRNA fragment
1eg0 – EcRPL11+RPL1+RPL6+RPS4+RPS5+RPS6+RPS7+RPS8+RPS15+RPS17+RPS20+fMet-tRNA+23S RRNA fragment – Cryo-EM
487d – GsRPL11+RPL1+RPL2+RPL9+RPL6+RPL14+RPL25 – Cryo-EM
1pn7 – TmRPL11+TtRPS12+P-site tRNA – Cryo-EM
1pn8 - TmRPL11+TtRPS12+E-site tRNA – Cryo-EM
1mvr - EcRPL11+RPS12+ mRNA triplet+16S RRNA fragments+23S RRNA fragments
5aff – RPL11 + RPL5 + symportin – Chaetomium thermophilum
References
- ↑ Demirci H, Gregory ST, Dahlberg AE, Jogl G. Multiple-site trimethylation of ribosomal protein L11 by the PrmA methyltransferase. Structure. 2008 Jul;16(7):1059-66. PMID:18611379 doi:10.1016/j.str.2008.03.016
- ↑ Gazda HT, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Schneider H, Darras N, Hasman C, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Zaucha JM, Glader B, Niemeyer C, Meerpohl JJ, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008 Dec;83(6):769-80. PMID:19061985 doi:S0002-9297(08)00589-2
