Ribosomal protein L5
From Proteopedia
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== Function == | == Function == | ||
[[Ribosomal protein L5]] (RPL5) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L5/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 5S RRNA from the large subunit. In the archaea like in ''Haloarcula marismortui'', the L5 is called L5P (RPL5P). The 3D structure of the | [[Ribosomal protein L5]] (RPL5) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L5/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. It is known to bind to the 5S RRNA from the large subunit. In the archaea like in ''Haloarcula marismortui'', the L5 is called L5P (RPL5P). The 3D structure of the | ||
| - | Ribosomal protein L5 complex with 5S RNA from Thermus thermophilus, (PDB code [[1mji]]) is shown to the right. | + | Ribosomal protein L5 complex with 5S RNA from Thermus thermophilus, (PDB code [[1mji]]) is shown to the right<ref>PMID:12515387</ref>. |
== Relevance == | == Relevance == | ||
Mutations in RPL5 are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients<ref>PMID:19061985</ref>. | Mutations in RPL5 are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients<ref>PMID:19061985</ref>. | ||
Revision as of 09:34, 29 September 2017
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3D Structures of Ribosomal protein L5
Updated on 29-September-2017
References
- ↑ Perederina A, Nevskaya N, Nikonov O, Nikulin A, Dumas P, Yao M, Tanaka I, Garber M, Gongadze G, Nikonov S. Detailed analysis of RNA-protein interactions within the bacterial ribosomal protein L5/5S rRNA complex. RNA. 2002 Dec;8(12):1548-57. PMID:12515387
- ↑ Gazda HT, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, Schneider H, Darras N, Hasman C, Sieff CA, Newburger PE, Ball SE, Niewiadomska E, Matysiak M, Zaucha JM, Glader B, Niemeyer C, Meerpohl JJ, Atsidaftos E, Lipton JM, Gleizes PE, Beggs AH. Ribosomal protein L5 and L11 mutations are associated with cleft palate and abnormal thumbs in Diamond-Blackfan anemia patients. Am J Hum Genet. 2008 Dec;83(6):769-80. PMID:19061985 doi:S0002-9297(08)00589-2
