Spermidine/spermine N-acetyltransferase

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Line 18: Line 18:
**[[2f5i]], [[2b5g]], [[2g3t]] – hSSAT1<br />
**[[2f5i]], [[2b5g]], [[2g3t]] – hSSAT1<br />
**[[2b3u]] – hSSAT1 (mutant)<br />
**[[2b3u]] – hSSAT1 (mutant)<br />
-
**[[5cnp]] – VcSSAT – ''Vibrio cholerae''<br />
+
**[[5cnp]], [[5ug4]] – VcSSAT – ''Vibrio cholerae''<br />
**[[4r9m]] – SSAT – ''Escherichia coli''<br />
**[[4r9m]] – SSAT – ''Escherichia coli''<br />
Line 34: Line 34:
**[[4r87]] – VcSSAT + spermine + CoA <br />
**[[4r87]] – VcSSAT + spermine + CoA <br />
**[[4ncz]] – VcSSAT + sulfonate derivative<br />
**[[4ncz]] – VcSSAT + sulfonate derivative<br />
 +
**[[5wif]] – SSAT + methoxy-methoxy–ethoxy-ethane - ''Yersinia pestis''<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 17:30, 5 October 2017

Human SSAT1 dimer complex with acetyl-spermine-S-CoA, 2jev

Drag the structure with the mouse to rotate

3D structures of SSAT

05-October-2017


References

  1. Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008 Jun;294(6):E995-1010. doi:, 10.1152/ajpendo.90217.2008. Epub 2008 Mar 18. PMID:18349109 doi:http://dx.doi.org/10.1152/ajpendo.90217.2008
  2. Allen WL, McLean EG, Boyer J, McCulla A, Wilson PM, Coyle V, Longley DB, Casero RA Jr, Johnston PG. The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells. Mol Cancer Ther. 2007 Jan;6(1):128-37. PMID:17237273 doi:http://dx.doi.org/10.1158/1535-7163.MCT-06-0303
  3. Hegde SS, Chandler J, Vetting MW, Yu M, Blanchard JS. Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase. Biochemistry. 2007 Jun 19;46(24):7187-95. Epub 2007 May 22. PMID:17516632 doi:10.1021/bi700256z

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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