Sandbox k11v
From Proteopedia
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== Introduction == | == Introduction == | ||
| - | Amyloid fibrils were first assumed to be the agents of Amyloid diseases,including Alzheimer’s,Parkinson’s and the prion conditions.But studies from many laboratories suggest that the reason for this disorder are lower molecular weight entities known as small amyloid oligomers | + | Amyloid fibrils were first assumed to be the agents of Amyloid diseases,including Alzheimer’s,Parkinson’s and the prion conditions.But studies from many laboratories suggest that the reason for this disorder are lower molecular weight entities known as small amyloid oligomers,instead of the associated protein fibrils.Segment of amyloid forming protein <scene name='77/771966/2wj7_full_structure/1'>alpha-beta crystallin</scene> makes oligomeric complex which exhibits properties of other amyloid oligomers.They are rich in beta-sheet structure and these oligomer can be identified by a conformational antibody(A11) that binds oligomers but not fibrils,irrespective of sequence of constituent protein.This protein is a chaperone that forms amyloid fibrils.The structure of oligomer shows a cylindrical barrel,made up of <scene name='77/771966/Six_anti-parallel_protein_abc/1'>six anti-parallel protein strands</scene> known as cylindrin.This segment(coloured in black) termed as <scene name='77/771966/Cylindrin_of_one_subunit/1'>K11V</scene> forms the cylindrin structure. |
== Molecular Tour == | == Molecular Tour == | ||
Revision as of 08:43, 4 November 2017
Toxic Amyloid Small Oligomer’s atomic view
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References
- ↑ Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391 doi:10.1126/science.1213151
