Sandbox k11v
From Proteopedia
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==Toxic Amyloid Small Oligomer’s atomic view== | ==Toxic Amyloid Small Oligomer’s atomic view== | ||
| - | <StructureSection load=' | + | <StructureSection load='3l1g' size='340' side='right' caption='Structure of alpha-beta crystallin.PDB Id:3l1g' scene=''> |
The interactive Molecular Tour below assumes that you are familiar with the journal article<ref>PMID:22403391</ref>. | The interactive Molecular Tour below assumes that you are familiar with the journal article<ref>PMID:22403391</ref>. | ||
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== Introduction == | == Introduction == | ||
| - | Amyloid fibrils were first assumed to be the agents of Amyloid diseases,including Alzheimer’s,Parkinson’s and the prion conditions.But studies from many laboratories suggest that the reason for this disorder are lower molecular weight entities known as small amyloid oligomers,instead of the associated protein fibrils.Segment of amyloid forming protein <scene name='77/771966/ | + | Amyloid fibrils were first assumed to be the agents of Amyloid diseases,including Alzheimer’s,Parkinson’s and the prion conditions.But studies from many laboratories suggest that the reason for this disorder are lower molecular weight entities known as small amyloid oligomers,instead of the associated protein fibrils.Segment of amyloid forming protein <scene name='77/771966/3l1g_full_structure/1'>alpha-beta crystallin</scene> makes oligomeric complex which exhibits properties of other amyloid oligomers.They are rich in beta-sheet structure and these oligomer can be identified by a conformational antibody(A11) that binds oligomers but not fibrils,irrespective of sequence of constituent protein.This protein is a chaperone that forms amyloid fibrils.The structure of oligomer shows a cylindrical barrel,made up of six anti-parallel protein strands known as cylindrin.This segment(coloured in black) termed as <scene name='77/771966/K11v_in_black/1'>K11V</scene> forms the cylindrin structure. |
== Molecular Tour == | == Molecular Tour == | ||
Oligomer forming segment of ABC were identified by inspection of its 3D structure and by applying the Rosetta-Profile algorithm to its sequence.Two segments of high amyloidogenic propensity,with sequences KVKVLG and GDVIEV (where D indicates Asp; E, Glu; G, Gly; I, Ile; K, Lys; and V, Val). | Oligomer forming segment of ABC were identified by inspection of its 3D structure and by applying the Rosetta-Profile algorithm to its sequence.Two segments of high amyloidogenic propensity,with sequences KVKVLG and GDVIEV (where D indicates Asp; E, Glu; G, Gly; I, Ile; K, Lys; and V, Val). | ||
| - | The entire 11-residue segment KVKVLGDVIEV forms a <scene name='77/771966/ | + | The entire 11-residue segment KVKVLGDVIEV forms a <scene name='77/771966/K11v_in_black/1'>hairpin loop</scene> in the 3D structure of ABC. |
== Relevance == | == Relevance == | ||
Revision as of 13:12, 4 November 2017
Toxic Amyloid Small Oligomer’s atomic view
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References
- ↑ Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391 doi:10.1126/science.1213151
