Sandbox k11v
From Proteopedia
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==Toxic Amyloid Small Oligomer’s atomic view== | ==Toxic Amyloid Small Oligomer’s atomic view== | ||
| - | <StructureSection load=' | + | <StructureSection load='' size='340' side='right' caption='Structure of alpha-beta crystallin.PDB Id:3l1g' scene=''> |
The interactive Molecular Tour below assumes that you are familiar with the journal article<ref>PMID:22403391</ref>. | The interactive Molecular Tour below assumes that you are familiar with the journal article<ref>PMID:22403391</ref>. | ||
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The entire 11-residue segment KVKVLGDVIEV forms a <scene name='77/771966/K11v_in_black/1'>hairpin loop</scene> in the 3D structure of ABC.The six residue segment GDVIEV ,termed <scene name='77/771966/Gdviev_black/1'>G6V</scene>,forms fibrils and microcrystals.THe microcrystals enabled us to determine the atomic structure of G6V, which proved to be a standard class 2 steric zipper, essentially an amyloid-like protofilament. | The entire 11-residue segment KVKVLGDVIEV forms a <scene name='77/771966/K11v_in_black/1'>hairpin loop</scene> in the 3D structure of ABC.The six residue segment GDVIEV ,termed <scene name='77/771966/Gdviev_black/1'>G6V</scene>,forms fibrils and microcrystals.THe microcrystals enabled us to determine the atomic structure of G6V, which proved to be a standard class 2 steric zipper, essentially an amyloid-like protofilament. | ||
| - | [[Image:Table_abc_first_ok.jpg]] | + | [[Image:Table_abc_first_ok.jpg | thumb | 400px | centre | Structure ]] |
Revision as of 14:40, 4 November 2017
Toxic Amyloid Small Oligomer’s atomic view
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References
- ↑ Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 9;335(6073):1228-31. PMID:22403391 doi:10.1126/science.1213151
