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Sandbox Reserved 1395
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== Disease == | == Disease == | ||
'''Sickle Cell Anemia''' | '''Sickle Cell Anemia''' | ||
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For the most part, amino acid sequences can be slightly different, but sometimes a change in the sequence can have a large impact. For example, in sickle cell anemia, glutamate 6 in the beta chain is mutated to valine, resulting in a structural change that allows hemoglobin to stick to each other and create stiff fibers, which creates the sickle shape in blood cells. | For the most part, amino acid sequences can be slightly different, but sometimes a change in the sequence can have a large impact. For example, in sickle cell anemia, glutamate 6 in the beta chain is mutated to valine, resulting in a structural change that allows hemoglobin to stick to each other and create stiff fibers, which creates the sickle shape in blood cells. | ||
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== Structural highlights == | == Structural highlights == | ||
| - | Hemoglobin is made of four protein chains. Each chain looks like myoglobin, which is used to store oxygen in muscles. Each individual chain has a heme group that has an iron atom that allows oxygen to bind. Of the chains, two are beta chains and two are alpha chains. | + | Hemoglobin is made of four protein chains. Each chain looks like myoglobin, which is used to store oxygen in muscles. Each individual chain has a <scene name='77/777715/Heme_groups/1'>heme group</scene> that has an iron atom that allows oxygen to bind. Of the chains, two are beta chains and two are alpha chains. |
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In the chain, the heme group has iron that allows the oxygen to bind. | In the chain, the heme group has iron that allows the oxygen to bind. | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 21:51, 22 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Hemoglobin
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