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Sandbox Reserved 1395

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== Diseases ==
== Diseases ==
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'''Sickle Cell Anemia'''
'''Sickle Cell Anemia'''
For the most part, amino acid sequences can be slightly different, but sometimes a change in the sequence can have a large impact. For example, in sickle cell anemia, glutamate 6 in the beta chain is mutated to valine, resulting in a structural change that allows hemoglobin to stick to each other and create stiff fibers, which creates the sickle shape in blood cells. These fibers are helpful because the malaria virus cannot live in blood cells with them, but can also lead to rupture of the blood cell, causing a loss of hemoglobin.
For the most part, amino acid sequences can be slightly different, but sometimes a change in the sequence can have a large impact. For example, in sickle cell anemia, glutamate 6 in the beta chain is mutated to valine, resulting in a structural change that allows hemoglobin to stick to each other and create stiff fibers, which creates the sickle shape in blood cells. These fibers are helpful because the malaria virus cannot live in blood cells with them, but can also lead to rupture of the blood cell, causing a loss of hemoglobin.
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'''Thalassemia'''
'''Thalassemia'''

Revision as of 18:18, 1 March 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

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Hemoglobin

This is hemoglobin. The chains and heme groups can be seen.

Drag the structure with the mouse to rotate
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