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Adenosine A2A receptor
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== Relevance == | == Relevance == | ||
| - | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by caffeine producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]]. | + | A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see [[G protein-coupled receptor]]. A2AR is blocked by <scene name='54/540144/5mzp_caffeine/1'>caffeine</scene> producing the arousal effect.<ref>PMID:21734299</ref> For details see [[Caffeine]]. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 07:47, 5 June 2018
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3D Structures of adenosine A2A receptor
Updated on 05-June-2018
3eml – hA2AR/lysozyme + antagonist – human
5k2a, 5k2b, 5k2c, 5k2d – hA2AR/cytochrome b562
5iu4, 5iu7, 5iu8, 5iua, 5iub – hA2AR/cytochrome b562 (mutant) + inhibitor
4ug2, 4uhr – hA2AR (mutant) + inhibitor
5g53 – hA2AR + G protein
3qak – hA2AR/lysozyme + agonist
2ydo – hA2AR (mutant) + adenosine
2ydv, 5wf5, 5wf6 – hA2AR (mutant) + agonist
3pwh, 3rey, 3rfm, 3uza, 3uzc – hA2AR (mutant) + antagonist
3rfm – hA2AR (mutant) + caffeine
3vg9, 3vga – hA2AR (mutant) + antibody
5jtb, 5nlx, 5nm2, 5nm4, 5uvi, 5vra – hA2AR/cytochrome b562
5olg, 5olh, 5olo, 5olv, 5olz, 5om1, 5om4 – hA2AR/cytochrome b562 (mutant)
4eiy – hA2AR/cytochrome b562 + antagonist
5uig, 6aqf – hA2AR/cytochrome b562 (mutant) + antagonist
5mzj – hA2AR/cytochrome b562 (mutant) + theophylline
5mzp – hA2AR/cytochrome b562 (mutant) + caffeine
5n2r – hA2AR/cytochrome b562 (mutant) + xanthine derivative
References
- ↑ Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18. PMID:21593763 doi:10.1038/nature10136
- ↑ Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PMID:21734299 doi:http://dx.doi.org/10.1523/JNEUROSCI.6730-10.2011
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