Sandbox1014

Cytochrome P450 3A4 (CYP3A4) is in the heme-thiolate monooxygenase enzyme family meaning the protein contains a heme group with an iron atom. Enzymes in Cytochrome P450 are oxidizing enzymes and CYP3A4 works in the body oxidizing foreign molecules such as toxins and drugs[1][2]. It appears almost half of the marketed pharmaceutical drugs are metabolized by CYP3A4 [1] All Cytochrome P450 are essential enzymes for metabolism and the enzyme CYP3A4 is the most important. [2] Primarily found in the liver and intestine, CYP3A4 is localized in the endoplasmic reticulum membrane [3] and are present in all eukaryotic organisms as well as some prokaryotes[3]. While CYP3A4's role in drug metabolism are numerous, they are often aiding deactivation through facilitated excretion from the system or by direct inactivation.

시토크롬P450 3A4(CYP3A4)는 헴-타이오레이트 모노옥시게나아제 효소의 패밀리에 속합니다. 이 패밀리는 철 원자를 가지고 있는 헴 그룹을 포함합니다.adf

<scene name='79/792536/Alpha/1'>알파 나선구조</scene>

<scene name='79/792536/Heme_binding/1'>heme biding site</scene>