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Nucleoside diphosphate kinase

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<StructureSection load='1ucn' size='350' side='right' caption='Human nucleoside diphosphate kinase complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry [[1ucn]])' scene='48/487511/Cv/1'>
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<StructureSection load='' size='350' side='right' caption='Human nucleoside diphosphate kinase complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry [[1ucn]])' scene='48/487511/Cv/1'>
== Function ==
== Function ==
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**[[3emt]], [[3ena]] - ApNDK (mutant) + GDP derivative<br />
**[[3emt]], [[3ena]] - ApNDK (mutant) + GDP derivative<br />
**[[3q86]] - SaNDK + GTP<br />
**[[3q86]] - SaNDK + GTP<br />
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[[4fky]] - TbNDK + GTP<br />
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**[[4fky]] - TbNDK + GTP<br />
*NDK complex with uridine derivative
*NDK complex with uridine derivative

Revision as of 19:49, 15 August 2018

Human nucleoside diphosphate kinase complex with ADP, phosphate, TRIS and Ca+2 ion (green) (PDB entry 1ucn)

Drag the structure with the mouse to rotate

3D structures of nucleoside diphosphate kinase

Updated on 15-August-2018

References

  1. ↑ Janin J, Dumas C, Morera S, Xu Y, Meyer P, Chiadmi M, Cherfils J. Three-dimensional structure of nucleoside diphosphate kinase. J Bioenerg Biomembr. 2000 Jun;32(3):215-25. PMID:11768305
  2. ↑ Qiu Y, Zhao D, Butenschon VM, Bauer AT, Schneider SW, Skolnik EY, Hammes HP, Wieland T, Feng Y. Nucleoside diphosphate kinase B deficiency causes a diabetes-like vascular pathology via up-regulation of endothelial angiopoietin-2 in the retina. Acta Diabetol. 2016 Feb;53(1):81-9. doi: 10.1007/s00592-015-0752-x. Epub 2015 Apr, 23. PMID:25900369 doi:http://dx.doi.org/10.1007/s00592-015-0752-x
  3. ↑ Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J. Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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