5dae
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5dae' size='340' side='right' caption='[[5dae]], [[Resolution|resolution]] 1.40Å' scene=''> | <StructureSection load='5dae' size='340' side='right' caption='[[5dae]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5dae]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DAE FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5dae]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aedae Aedae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DAE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DAE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dae OCA], [http://pdbe.org/5dae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dae RCSB], [http://www.ebi.ac.uk/pdbsum/5dae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dae ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AAEL006007 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7159 AEDAE])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dae OCA], [http://pdbe.org/5dae PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dae RCSB], [http://www.ebi.ac.uk/pdbsum/5dae PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dae ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Blood-feeding exoparasites are rich sources of protease inhibitors, and the mosquito Aedes aegypti, which is a vector of Dengue virus, Yellow fever virus, Chikungunya virus and Zika virus, is no exception. AaTI is a single-domain, noncanonical Kazal-type serine proteinase inhibitor from A. aegypti that recognizes both digestive trypsin-like serine proteinases and the central protease in blood clotting, thrombin, albeit with an affinity that is three orders of magnitude lower. Here, the 1.4 A resolution crystal structure of AaTI is reported from extremely tightly packed crystals ( approximately 22% solvent content), revealing the structural determinants for the observed inhibitory profile of this molecule. | ||
| + | |||
| + | High-resolution structure of a Kazal-type serine protease inhibitor from the dengue vector Aedes aegypti.,Torquato RJS, Lu S, Martins NH, Tanaka AS, Pereira PJB Acta Crystallogr F Struct Biol Commun. 2017 Aug 1;73(Pt 8):469-475. doi:, 10.1107/S2053230X17010007. Epub 2017 Jul 26. PMID:28777090<ref>PMID:28777090</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5dae" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Aedae]] | ||
[[Category: Pereira, P J.B]] | [[Category: Pereira, P J.B]] | ||
[[Category: Tanaka, A S]] | [[Category: Tanaka, A S]] | ||
Revision as of 07:43, 12 September 2018
Kazal type inhibitor from salivary glands of Aedes aegypti mosquito
| |||||||||||
Categories: Aedae | Pereira, P J.B | Tanaka, A S | Torquato, R J.S | Anticoagulant | Inhibitor | Kazal | Protein binding | Trypsin
