Sulfotransferase

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<StructureSection load='' size='450' side='right' scene='49/491888/Cv/2' caption='Human estrogen sulfotransferase dimer complex with cofactor PAP, [[1hy3]]'>
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<StructureSection load='' size='350' side='right' scene='49/491888/Cv/2' caption='Human estrogen sulfotransferase dimer complex with cofactor PAP, [[1hy3]]'>
== Function ==
== Function ==
-
'''Sulfotransferase''' (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system<ref>PMID:20136513</ref>. The various human STs are named SULT### and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).
+
'''Sulfotransferase''' (ST) are enzymes which catalyze the transfer of a sulfate group from a donor molecule to an acceptor alcohol or amine. The acceptors are hormones, neurotransmitters, drugs and xenobiotic compounds. The addition of a charged chemical moiety to the above carbon-rich water-insoluble molecules, make them more soluble and thus transportable in the circulatory system<ref>PMID:20136513</ref>. The various human STs are named SULT1, SULT2, SULT4 and differ in their tissue distribution and substrate specificities. The most common donor molecule is 3’-phosphoadenosine-5’-phosphosulfate (PAP).
== Relevance ==
== Relevance ==
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**[[1aqu]] – mST + estradiol + PAP<BR />
**[[1aqu]] – mST + estradiol + PAP<BR />
**[[1bo6]] - mST + VO4 + PAP<BR />
**[[1bo6]] - mST + VO4 + PAP<BR />
-
**[[1hy3]] - hST (mutant) + PAP – human<BR />
 
-
**[[4jvl]] - hST (mutant) + estradiol + PAP<br />
 
-
**[[4jvm]], [[4jvn]] - hST (mutant) + flame retardant + PAP<br />
 
- 
-
**[[1g3m]] - hST + tetrachloro-biphenyl-diol + PAP<BR />
 
*Arylsulfate sulfotransferase
*Arylsulfate sulfotransferase
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**[[4p05]] – EcST (mutant) + nitrophenylsulfate <br />
**[[4p05]] – EcST (mutant) + nitrophenylsulfate <br />
-
*Hydroxysteroid sulfotransferase
 
- 
-
**[[1efh]] - hST + PAP<BR />
 
*Alcohol sulfotransferase
*Alcohol sulfotransferase
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**[[1j99]] - hST + androsterone derivative<BR />
**[[1j99]] - hST + androsterone derivative<BR />
**[[1ov4]] - hST (mutant) + androsterone derivative
**[[1ov4]] - hST (mutant) + androsterone derivative
- 
-
*Pregnenolone sulfotransferase
 
- 
-
**[[1q1q]] - hST + PAP<BR />
 
- 
-
*Cholesterol sulfotransferase
 
- 
-
**[[1q1z]] - hST + PAP<BR />
 
-
**[[1q20]], [[1q22]] - hST + cholesterol derivative + PAP<BR />
 
*Cytosolic sulfotransferase
*Cytosolic sulfotransferase
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**[[1vkj]] - mST (mutant) + PAP<BR />
**[[1vkj]] - mST (mutant) + PAP<BR />
-
**[[1t8t]] - hST catalytic domain + PAP<BR />
 
**[[3f5f]] – ST/MBP + PAP - chicken<br />
**[[3f5f]] – ST/MBP + PAP - chicken<br />
-
**[[5t03]], [[5t05]] – zST/MBP + PAP + hexasaccharide - zebrafish<br />
+
**[[5t03]], [[5t05]], [[5t0a]] – zST/MBP + PAP + hexasaccharide - zebrafish<br />
*Heparan sulfate glucosamine 3-o-sulfotransferase
*Heparan sulfate glucosamine 3-o-sulfotransferase
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**[[3ap3]] - hST + PAP<BR />
**[[3ap3]] - hST + PAP<BR />
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*Sulfotransferase 1C2
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*'''Human sulfotransferase'''
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**[[2ad1]] – hST<br />
+
*''Sulfotransferase 1A1''
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**[[3bfx]] - hST (mutant) + PAP<BR />
+
-
**[[2gwh]] - hST + pentachlorophenol + PAP<BR />
+
-
 
+
-
*Sulfotransferase 1C3
+
-
 
+
-
**[[2h8k]] - hST + PAP<br />
+
-
 
+
-
*Sulfotransferase 1A4
+
-
 
+
-
**[[1zd1]] – hST
+
-
 
+
-
*Sulfotransferase 1A3
+
-
 
+
-
**[[2a3r]] – hST + dopamine + PAP<BR />
+
-
**[[1cjm]] - hST + sulfate
+
-
 
+
-
*Sulfotransferase 1A1
+
**[[3u3j]], [[4gra]] - hST + PAP<BR />
**[[3u3j]], [[4gra]] - hST + PAP<BR />
**[[2d06]] – hST + estradiol + PAP<BR />
**[[2d06]] – hST + estradiol + PAP<BR />
 +
**[[1ls6]] - hST + p-nitrophenol + PAP<BR />
**[[3qvu]], [[3u3r]] – hST (mutant) + p-nitrophenol + PAP<BR />
**[[3qvu]], [[3u3r]] – hST (mutant) + p-nitrophenol + PAP<BR />
**[[3qvv]] - hST (mutant) + hydroxyl-chromene-carbonitrile + PAP<BR />
**[[3qvv]] - hST (mutant) + hydroxyl-chromene-carbonitrile + PAP<BR />
-
**[[1ls6]] - hST + p-nitrophenol + PAP<BR />
 
**[[3u3k]] - hST + 3-naphthol + PAP<BR />
**[[3u3k]] - hST + 3-naphthol + PAP<BR />
**[[3u3m]], [[3u3o]] - hST + 3-cyano-7-hydroxycoumarin + PAP<BR />
**[[3u3m]], [[3u3o]] - hST + 3-cyano-7-hydroxycoumarin + PAP<BR />
-
*Sulfotransferase 1A2
+
*''Sulfotransferase 1A2''
**[[1z28]], [[1z29]] - hST + hydroxyl-acetylamino fluorine
**[[1z28]], [[1z29]] - hST + hydroxyl-acetylamino fluorine
-
*Sulfotransferase 1B1
+
*''Sulfotransferase 1A3''
 +
 
 +
**[[2a3r]] – hST + dopamine + PAP<BR />
 +
**[[1cjm]] - hST + sulfate
 +
 
 +
*''Sulfotransferase 1A4''
 +
 
 +
**[[1zd1]] – hST
 +
 
 +
*''Sulfotransferase 1B1''
**[[2z5f]] - hST + PAP<BR />
**[[2z5f]] - hST + PAP<BR />
**[[3ckl]] - hST + resveratrol + PAP<BR />
**[[3ckl]] - hST + resveratrol + PAP<BR />
-
*Sulfotransferase 2A1
+
*''Sulfotransferase 1C2''
 +
 
 +
**[[2ad1]] – hST<br />
 +
**[[3bfx]] - hST (mutant) + PAP<BR />
 +
**[[2gwh]] - hST + pentachlorophenol + PAP<BR />
 +
 
 +
*''Sulfotransferase 1C3''
 +
 
 +
**[[2h8k]] - hST + PAP<br />
 +
 
 +
*''Sulfotransferase 1E1 or estrogen sulfotransferase''
 +
 
 +
**[[1hy3]] - hST (mutant) + PAP – human<BR />
 +
**[[4jvl]] - hST (mutant) + estradiol + PAP<br />
 +
**[[4jvm]], [[4jvn]] - hST (mutant) + flame retardant + PAP<br />
 +
**[[1g3m]] - hST + tetrachloro-biphenyl-diol + PAP<BR />
 +
 
 +
*''Sulfotransferase 2A1''
**[[2qp3]], [[2qp4]] - hST (mutant) + aetiocholanolone<BR />
**[[2qp3]], [[2qp4]] - hST (mutant) + aetiocholanolone<BR />
**[[3f3y]] - hST + lithocholic acid + PAP<BR />
**[[3f3y]] - hST + lithocholic acid + PAP<BR />
**[[4ifb]] - hST (mutant) + PAP<br />
**[[4ifb]] - hST (mutant) + PAP<br />
 +
 +
*''Sulfotransferase 2A3 or hydroxysteroid sulfotransferase''
 +
 +
**[[1efh]] - hST + PAP<BR />
 +
 +
*''Sulfotransferase 2B1a or pregnenolone sulfotransferase''
 +
 +
**[[1q1q]] - hST + PAP<BR />
 +
 +
*''Sulfotransferase 2B1b or cholesterol sulfotransferase''
 +
 +
**[[1q1z]] - hST + PAP<BR />
 +
**[[1q20]], [[1q22]] - hST + cholesterol derivative + PAP<BR />
 +
 +
*''Sulfotransferase 3A1 heparan sulfate sulfotransferase''
 +
 +
**[[1t8t]] - hST catalytic domain + PAP<BR />
 +
 +
*''Sulfotransferase 4A1''
 +
 +
**[[1zd1]] - hST <br />
 +
 +
*'''Mouse sulfotransferase'''
 +
 +
*''Sulfotransferase 7A1''
 +
 +
**[[5x2b]] - mST + PAP<BR />
*STF0 sulfotransferase
*STF0 sulfotransferase

Revision as of 18:43, 21 September 2018

Human estrogen sulfotransferase dimer complex with cofactor PAP, 1hy3

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3D structures of sulfotransferase

Updated on 21-September-2018


References

  1. ↑ Malojcic G, Glockshuber R. The PAPS-independent aryl sulfotransferase and the alternative disulfide bond formation system in pathogenic bacteria. Antioxid Redox Signal. 2010 Oct;13(8):1247-59. doi: 10.1089/ars.2010.3119. PMID:20136513 doi:http://dx.doi.org/10.1089/ars.2010.3119
  2. ↑ Yalcin EB, More V, Neira KL, Lu ZJ, Cherrington NJ, Slitt AL, King RS. Downregulation of sulfotransferase expression and activity in diseased human livers. Drug Metab Dispos. 2013 Sep;41(9):1642-50. doi: 10.1124/dmd.113.050930. Epub 2013, Jun 17. PMID:23775849 doi:http://dx.doi.org/10.1124/dmd.113.050930
  3. ↑ Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem. 2002 May 17;277(20):17928-32. Epub 2002 Mar 7. PMID:11884392 doi:http://dx.doi.org/10.1074/jbc.M111651200

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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