Virus protease

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<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
<StructureSection load='' size='350' side='right' caption='Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry [[1cqq]])' scene='55/554890/Cv/1'>
__TOC__
__TOC__
== Function ==
== Function ==
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'''3C protease''' (3CP) is a virus cysteine protease which has essential role in viral replication. 3CP cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> For more details on Foot and Mouth Disease virus 3C protease see [[FMDV 3C]].
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'''Virus protease''' or '''3C protease''' are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.<ref>PMID:17305557</ref> F
== Disease ==
== Disease ==
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3CP is an attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis.
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Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus. Coxsakievirus causes the human diseases myocarditis and pericarditis.
== Structural highlights ==
== Structural highlights ==
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3CP - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
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Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The <scene name='55/554890/Cv/6'>active site triad contains Cys147, His40 and Glu71</scene> (PDB entry [[1cqq]]).<ref>PMID:10500114</ref> <scene name='55/554890/Cv/5'>Whole binding site</scene>.
See also<br />
See also<br />
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*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Molecular Playground/Dengue Virus Protease]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
*[[Viability of a drug-resistant HIV-1 protease mutant]]<br />
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*[[Molecular Playground/Dengue Virus Protease]]
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*[[Molecular Playground/Dengue Virus Protease]]<br />
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*[[FMDV 3C]] for Foot-and-Mouth virus protease
</StructureSection>
</StructureSection>
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*'''Hepatitis A virus protease'''
*'''Hepatitis A virus protease'''
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**[[2h9h]], [[2hal]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
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**[[1hav]] – HAVP (mutant) – hepatitis A virus <br />
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**[[2h9h]], [[2hal]] – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor<br />
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**[[2h6m]] – HAVP + peptide inhibitor <br />
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**[[1qa7]], [[3r0f]] – HAVP (mutant) + inhibitor <br />
*'''Hepatitis C virus protease'''
*'''Hepatitis C virus protease'''
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*'''Foot-and-Mouth Disease virus protease'''
*'''Foot-and-Mouth Disease virus protease'''
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**[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus
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**[[2bhg]] – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus <br />
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**[[2jqf]], [[2j92]], [[5hm2]] – FMDV (mutant) <br />
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**[[2wv4]], [[2wv5]] – FMDV (mutant) + peptide <br />
*'''Infectious Bronchitis virus protease'''
*'''Infectious Bronchitis virus protease'''
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**[[2q6d]] – IBV – infectious bronchitis virus <br />
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**[[2q6d]], [[4x2z]] – IBV – infectious bronchitis virus <br />
**[[2q6f]] – IBV + inhibitor
**[[2q6f]] – IBV + inhibitor
*'''Yellowtail ascites virus protease'''
*'''Yellowtail ascites virus protease'''
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**[[4izj]], [[4izk]] – YAV Vp4 (mutant) – yellowtail ascites virus
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**[[4cx8]], [[4b07]], [[4b0t]] – YAV – yellowtail ascites virus<br />
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**[[4b08]] – YAV + inhibitor<br />
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**[[4izj]], [[4izk]] – YAV Vp4 (mutant)
*'''Pseudorabies virus protease'''
*'''Pseudorabies virus protease'''
**[[4cx8]] – YAV – pseudorabies virus<br />
**[[4cx8]] – YAV – pseudorabies virus<br />
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*'''Coxsakievirus protease'''
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**[[2vb0]], [[2zty]], [[2ztz]], [[3zyd]], [[3sj8]] – CSVP <br />
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**[[2zu1]], [[3zye]], [[3zz3]], [[3zz4]] – CSVP (mutant) <br />
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**[[2ztx]] – CSVP + Zn-H2S <br />
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**[[2zu3]], [[3zz5]], [[3zz6]], [[3zz7]], [[3zz8]], [[3zz9]], [[3zza]], [[3zzb]], [[3sji]] – CSVP + inhibitor <br />
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**[[3zzc]], [[3zzd]] – CSVP (mutant) + inhibitor <br />
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**[[3sj9]] – CSVP (mutant) + peptide inhibitor <br />
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*'''Human polio virus protease'''
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**[[1l1n]] – HPV <br />
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**[[2ijd]] – HPV (mutant) <br />
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*'''Human rhinovirus protease'''
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**[[2in2]] – HRVP – human rhinovirus - NMR <br />
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**[[1cqq]], [[2xya]], [[5fx5]], [[5fx6]], [[6ffn]], [[6ffs]] – HRVP + inhibitor <br />
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**[[2b0f]] – HRVP + inhibitor – NMR <br />
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**[[2h6m]] – HRVP + peptide inhibitor <br />
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*'''Human enterovirus protease'''
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**[[3osy]] – HEVP 71 – human enterovirus <br />
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**[[3zv8]] – HEVP 68 residues 1549-1731 <br />
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**[[3q3x]] – HEVP B (mutant) <br />
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**[[3q3y]] – HEVP B (mutant) + inhibitor <br />
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**[[3ruo]] – HEVP B + inhibitor <br />
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**[[3sjk]] – HEVP 71 (mutant) + peptide inhibitor <br />
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**[[3sjo]], [[5bpe]], [[5hxf]], [[5wq2]] – HEVP 71 + inhibitor <br />
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**[[3qzq]], [[3qzr]] – HEVP 71 (mutant) + inhibitor <br />
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**[[3zv9]], [[3zva]], [[3zvb]], [[3zvc]], [[3zvd]], [[3zve]], [[3zvf]], [[3zvg]] – HEVP 68 + inhibitor <br />
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'''Porcine epidemic diarrhea virus protease'''
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**[[5hyo]] – PEDVP – porcine epidemic diarrhea virus <br />
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'''Coronavirus protease'''
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**[[4wme]], [[4wmf]] – CVP (mutant)- coronavirus <br />
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'''SARS coronavirus protease'''
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**[[3e91]], [[3ea7]], [[3ea8]], [[3ea9]], [[3eaj]] – SCVP (mutant) – SARS coronavirus <br />
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**[[2amd]], [[2amq]], [[2gx4]], [[2z9g]], [[2z9j]], [[2z9k]], [[2z9l]], [[2zu5]], [[4mds]], [[4tww]], [[4twy]] – SCVP + inhibitor <br />
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'''Coronavirus HKU4 protease'''
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**[[2ynb]] – CVHP + inhibitor – BAT coronavirus <br />
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'''Echovirus 1 protease'''
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**[[5iyt]] – EV1P (mutant) + inhibitor – Echovirus 1 <br />
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'''Norovirus protease'''
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**[[5e0g]], [[5e0h]], [[5e0j]] – NVP (mutant)+ peptide inhibitor – Norovirus <br />
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**[[3ur9]], [[4imq]], [[4xbb]], [[4xbc]], [[4xbd]], [[5dg6]], [[5dgj]], [[5tg1]], [[5tg2]] – NVP residues 1101-1281 + inhibitor <br />
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'''Norovirus 3C-like protease'''
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**[[1wqs]] – NVLP – chiba virus <br />
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'''Gastroentritis virus protease'''
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**[[2amp]] – GEVP + inhibitor – gastroenteritis virus <br />
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'''Southampton virus protease'''
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**[[2iph]] – SVP + inhibitor – Southampton virus <br />
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'''West Nile virus protease'''
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**[[2ggv]] - WNVP (mutant) - West Nile virus<br />
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**[[2ijo]] - WNVP (mutant) + BPTI<br />
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**[[2yol]], [[5idk]], [[2fp7]] - WNVP + peptide inhibitor<br />
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**[[3e90]] - WNVP + inhibitor<br />
}}
}}

Revision as of 17:39, 8 October 2018

Structure of human rhinovirus 3C protease complex with inhibitor (PDB entry 1cqq)

Drag the structure with the mouse to rotate

3D Structures of Virus proteases

Updated on 08-October-2018

Porcine epidemic diarrhea virus protease

Coronavirus protease

SARS coronavirus protease

Coronavirus HKU4 protease

Echovirus 1 protease

Norovirus protease

Norovirus 3C-like protease

Gastroentritis virus protease

Southampton virus protease

West Nile virus protease

References

  1. ↑ Wanga QM, Chen SH. Human rhinovirus 3C protease as a potential target for the development of antiviral agents. Curr Protein Pept Sci. 2007 Feb;8(1):19-27. PMID:17305557
  2. ↑ Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. PMID:10500114

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