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Raptor

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<StructureSection load='5wbj' size='340' side='right' caption='Raptor (grey) in complex with human 4EBP1 peptide PDB code [[5wbj]]' scene=''>
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<StructureSection load='5wbj' size='340' side='right' caption='Raptor (grey) in complex with human 4EBP1 peptide (mustard) PDB code [[5wbj]]' scene=''>
'''Raptor''' (Rap) or '''R'''egulatory-'''A'''ssociated '''P'''rotein of '''TOR''' 1 binds mTOR which controls cell growth, p70 S6 kinase α (S6K1) and the the initiation factor 4E binding protein 1 (4EBP1). The binding of Rap to mTOR is necessary for the mTOR-catayzed phosphorylation of the initiation factor binding protein
'''Raptor''' (Rap) or '''R'''egulatory-'''A'''ssociated '''P'''rotein of '''TOR''' 1 binds mTOR which controls cell growth, p70 S6 kinase α (S6K1) and the the initiation factor 4E binding protein 1 (4EBP1). The binding of Rap to mTOR is necessary for the mTOR-catayzed phosphorylation of the initiation factor binding protein

Revision as of 09:38, 25 October 2018

Raptor (grey) in complex with human 4EBP1 peptide (mustard) PDB code 5wbj

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3D structures of raptor

Updated on 25-October-2018

5ef5 - Rap - Chaetomium thermophilum
5wbi - AtRap - Arabidopsis thaliana
5wbj - AtRap + 4EBP1 peptide
5wbk - AtRap + S6K1 peptide
5wbl - AtRap + PRAS40 peptide
6bcu - hRap + mTOR + target of rapamycin complex + Rheb + 4EBP1 peptide - human - Cryo EM
5h64 - hRap + mTOR + target of rapamycin complex - Cryo EM
6bcx - hRap + mTOR + target of rapamycin complex + 4EBP1 peptide - Cryo EM
5flc - hRap + mTOR + target of rapamycin complex + FKBP - Cryo EM
5fjl, 5fld - Rap fiber head domain - Siadenovirus A


References

  1. ↑ Chong ZZ, Shang YC, Maiese K. Cardiovascular disease and mTOR signaling. Trends Cardiovasc Med. 2011 Jul;21(5):151-5. doi: 10.1016/j.tcm.2012.04.005. PMID:22732551 doi:http://dx.doi.org/10.1016/j.tcm.2012.04.005

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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