Collagenase (non-MMP)

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Revision as of 06:36, 18 February 2019

Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 4arf)

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Updated on 18-February-2019

↑ Eckhard U, Schonauer E, Brandstetter H. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. J Biol Chem. 2013 May 23. PMID:23703618 doi:10.1074/jbc.M112.448548

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 == Structural highlights ==
-''Clostridium histolycum'' collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a <scene name='47/477092/Cv/3'>Zn+2 coordination site</scene>, a <scene name='47/477092/Cv/4'>substrate-recognition site</scene> and an <scene name='47/477092/Cv/6'>oxyanion hole</scene>.<ref>PMID:23703618</ref> <scene name='47/477092/Cv/7'>Click here to see surface of binding site</scene>.
+''Clostridium histolycum'' collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a <scene name='47/477092/Cv/8'>Zn+2 coordination site</scene>, a <scene name='47/477092/Cv/9'>substrate-recognition site</scene> and an <scene name='47/477092/Cv/10'>oxyanion hole</scene>.<ref>PMID:23703618</ref> Water molecules are shown as red spheres. <scene name='47/477092/Cv/11'>Click here to see surface of binding site</scene>.
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