Adenosine A2A receptor
From Proteopedia
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*<scene name='54/540144/Cv/8'>A2AR posses a ligand-binding cavity</scene>. | *<scene name='54/540144/Cv/8'>A2AR posses a ligand-binding cavity</scene>. | ||
*<scene name='54/540144/Cv/7'>Adenosine binding site</scene>. | *<scene name='54/540144/Cv/7'>Adenosine binding site</scene>. | ||
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| + | == 3D Structures of adenosine A2A receptor == | ||
| + | [[Adenosine A2A receptor 3D structures== | ||
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</StructureSection> | </StructureSection> | ||
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[[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br /> | [[5mzp]] – hA2AR/cytochrome b562 (mutant) + caffeine <br /> | ||
[[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br /> | [[5n2r]] – hA2AR/cytochrome b562 (mutant) + xanthine derivative <br /> | ||
| + | [[6gdg]] – hA2AR/TrxA + transducing β + G γ-I + adenylate cyclase-stimulating G α + antibody – Cryo EM<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:10, 28 February 2019
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3D Structures of adenosine A2A receptor
Updated on 28-February-2019
3eml – hA2AR/lysozyme + antagonist – human
5k2a, 5k2b, 5k2c, 5k2d – hA2AR/cytochrome b562
5iu4, 5iu7, 5iu8, 5iua, 5iub – hA2AR/cytochrome b562 (mutant) + inhibitor
4ug2, 4uhr – hA2AR (mutant) + inhibitor
5g53 – hA2AR + G protein
3qak – hA2AR/lysozyme + agonist
2ydo – hA2AR (mutant) + adenosine
2ydv, 5wf5, 5wf6 – hA2AR (mutant) + agonist
3pwh, 3rey, 3rfm, 3uza, 3uzc – hA2AR (mutant) + antagonist
3rfm – hA2AR (mutant) + caffeine
3vg9, 3vga – hA2AR (mutant) + antibody
5jtb, 5nlx, 5nm2, 5nm4, 5uvi, 5vra – hA2AR/cytochrome b562
5olg, 5olh, 5olo, 5olv, 5olz, 5om1, 5om4 – hA2AR/cytochrome b562 (mutant)
4eiy – hA2AR/cytochrome b562 + antagonist
5uig, 6aqf – hA2AR/cytochrome b562 (mutant) + antagonist
5mzj – hA2AR/cytochrome b562 (mutant) + theophylline
5mzp – hA2AR/cytochrome b562 (mutant) + caffeine
5n2r – hA2AR/cytochrome b562 (mutant) + xanthine derivative
6gdg – hA2AR/TrxA + transducing β + G γ-I + adenylate cyclase-stimulating G α + antibody – Cryo EM
References
- ↑ Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18. PMID:21593763 doi:10.1038/nature10136
- ↑ Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PMID:21734299 doi:http://dx.doi.org/10.1523/JNEUROSCI.6730-10.2011
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