Aminotransferase

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The <scene name='72/721044/Cv/3'>active site of histidinol-phosphate aminotransferase contains PLP</scene>.<ref>PMID:11294630</ref>
The <scene name='72/721044/Cv/3'>active site of histidinol-phosphate aminotransferase contains PLP</scene>.<ref>PMID:11294630</ref>
 +
==3D structures of aminotransferase==
 +
[[Aminotransferase 3D structures]]
</StructureSection>
</StructureSection>
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**[[3hdo]] – HPA – ''Geobacter metallireducens''<br />
**[[3hdo]] – HPA – ''Geobacter metallireducens''<br />
**[[4rae]] – MtHPA – ''Mycobacterium tuberculosis''<br />
**[[4rae]] – MtHPA – ''Mycobacterium tuberculosis''<br />
-
**[[4r8d]], [[5c6u]] – MtHPA + PLP <br />
+
**[[4r8d]], [[5c6u]], [[5yhv]] – MtHPA + PLP <br />
*Ornithine aminotransferase
*Ornithine aminotransferase
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**[[4cmd]] – NhBCAT + PLP – ''Nectria haematococca''<br />
**[[4cmd]] – NhBCAT + PLP – ''Nectria haematococca''<br />
**[[4cmf]] – NhBCAT + inhibitor <br />
**[[4cmf]] – NhBCAT + inhibitor <br />
-
**[[5e25]] – BCAT + PLP + ketoglutarate – ''Geoglobus acetivorans'' <br />
+
**[[5cm0]] – GaBCAT + PLP – ''Geoglobus acetivorans'' <br />
 +
**[[5e25]] – GaBCAT + PLP + ketoglutarate <br />
**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
**[[5ce8]] – BCAT + PLP – ''Thermoproteus uzoniensis'' <br />
**[[5u3f]] – MtBCAT + cycloserine <br />
**[[5u3f]] – MtBCAT + cycloserine <br />
 +
**[[6nst]] - BCAT – ''Pseudomonas aeruginosa''<br />
 +
**[[6gkr]] – TtBCAT + PLP – ''Thermobaculum terrenum'' <br />
 +
**[[6q8e]] – TtBCAT + PLP derivative <br />
 +
**[[6h65]] – TtBCAT + PLP – ''Haliangium ochraceum'' <br />
 +
**[[4whx]] – BCAT + PLP – ''Burkholderia pseudomallei'' <br />
*Aromatic amino acid aminotransferase
*Aromatic amino acid aminotransferase
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**[[4rkc]] – PsAROAT + PLP derivative - ''Psychrobacter''<br />
**[[4rkc]] – PsAROAT + PLP derivative - ''Psychrobacter''<br />
**[[4rkd]] – PsAROAT + PLP derivative + PLP<br />
**[[4rkd]] – PsAROAT + PLP derivative + PLP<br />
 +
**[[6hnb]] – CaAROAT – ''Candida albicans'' <br />
 +
**[[6hnu]] – CaAROAT + PLP + Phe<br />
*Tyrosine aminotransferase
*Tyrosine aminotransferase
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**[[3ihj]] – hALAAT 2 + PLP <br />
**[[3ihj]] – hALAAT 2 + PLP <br />
**[[3tcm]] – ALAAT 2 (mutant) + PLP derivative - barley<br />
**[[3tcm]] – ALAAT 2 (mutant) + PLP derivative - barley<br />
 +
 +
*Cysteine aminotransferase
 +
 +
**[[4w91]] – CYSAT + PLP – ''Brucella suis''<br />
*Glutamine aminotransferase
*Glutamine aminotransferase
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*WbpE aminotransferase
*WbpE aminotransferase
-
**[[3nu7]], [[3nu8]], [[3nub]], [[3nyu]] - PaWbpE + PLP derivative – ''Pseudomonas aeruginosa''<br />
+
**[[3nu7]], [[3nu8]], [[3nub]], [[3nyu]] - PaWbpE + PLP derivative <br />
**[[3nys]] - PaWbpE (mutant) + PLP <br />
**[[3nys]] - PaWbpE (mutant) + PLP <br />
**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
**[[3nyt]] - PaWbpE (mutant) + PLP derivative<br />
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*C-6’ aminotransferase
*C-6’ aminotransferase
-
**[[6cbo]] - AT – ''Micromonospora echinospora'' <br />
+
**[[6cbo]] - MeAT – ''Micromonospora echinospora'' <br />
 +
**[[5z83]] – MeAT + PLP <br />
 +
**[[5z8a]] – MeAT + PLP + JI-20A <br />
 +
**[[5z8k]] – MeAT + PLP + neomycin <br />
*Kynurenine aminotransferase
*Kynurenine aminotransferase
-
**[[5veh]] – AaKAT + PLP derivative <br />
+
**[[4wlh]], [[4wlj]], [[4wp0]] – hKAT 1 + PLP derivative <br />
-
**[[5vep]], [[5veq]], [[5ver]] – mKAT 3 + PLP derivative <br />
+
**[[5efs]], [[6d0a]] – hKAT 2 <br />
-
**[[4wlh]], [[4wlj]] – hKAT 1 + PLP derivative <br />
+
-
**[[5efs]] – hKAT 2 <br />
+
**[[5tf5]] – hKAT 2 + PLP derivative + inhibitor<br />
**[[5tf5]] – hKAT 2 + PLP derivative + inhibitor<br />
 +
**[[5vep]], [[5veq]], [[5ver]] – mKAT 3 + PLP derivative <br />
 +
**[[5veh]] – AaKAT + PLP derivative <br />
 +
 +
*Diaminopelargonic acid aminotransferase
 +
 +
**[[6erk]] – DPAAT + PLP – ''Psychrobacter cryohalolentis'' <br />
 +
 +
*D-phenylglycine aminotransferase
 +
 +
**[[6dvs]] – DPGAT – ''Pseudomonas stutzeri'' <br />
 +
 +
*Aminotransferase class II
 +
 +
**[[5z0q]] – AT2 + PLP – ''Erwinia tasmaniensis'' <br />
*Aminotransferase class III
*Aminotransferase class III

Revision as of 08:56, 14 March 2019

E. coli Histidinol-phosphate aminotransferase complex with PLP (PDB code 1gew)

Drag the structure with the mouse to rotate

3D structures of aminotransferase

Updated on 14-March-2019

References

  1. ↑ Mizuguchi H, Hayashi H, Miyahara I, Hirotsu K, Kagamiyama H. Characterization of histidinol phosphate aminotransferase from Escherichia coli. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):321-4. PMID:12686152
  2. ↑ Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P. Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. J Mol Biol. 1984 Apr 15;174(3):497-525. PMID:6143829 doi:http://dx.doi.org/10.1016/0022-2836(84)90333-4
  3. ↑ Kirsch JF, Eichele G, Ford GC, Vincent MG, Jansonius JN, Gehring H, Christen P. Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure. J Mol Biol. 1984 Apr 15;174(3):497-525. PMID:6143829 doi:http://dx.doi.org/10.1016/0022-2836(84)90333-4
  4. ↑ Haruyama K, Nakai T, Miyahara I, Hirotsu K, Mizuguchi H, Hayashi H, Kagamiyama H. Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Biochemistry. 2001 Apr 17;40(15):4633-44. PMID:11294630

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