4m2x
From Proteopedia
(Difference between revisions)
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==Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)== | ==Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)== | ||
| - | <StructureSection load='4m2x' size='340' side='right' caption='[[4m2x]], [[Resolution|resolution]] 2.26Å' scene=''> | + | <StructureSection load='4m2x' size='340' side='right'caption='[[4m2x]], [[Resolution|resolution]] 2.26Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4m2x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M2X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4m2x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M2X FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TMQ:TRIMETREXATE'>TMQ</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TMQ:TRIMETREXATE'>TMQ</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folA, dfrA, Rv2763c, MT2833, MTV002.28c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m2x OCA], [http://pdbe.org/4m2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m2x RCSB], [http://www.ebi.ac.uk/pdbsum/4m2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m2x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m2x OCA], [http://pdbe.org/4m2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m2x RCSB], [http://www.ebi.ac.uk/pdbsum/4m2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m2x ProSAT]</span></td></tr> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Jung, H]] | [[Category: Jung, H]] | ||
[[Category: Sacchettini, J C]] | [[Category: Sacchettini, J C]] | ||
Revision as of 08:30, 3 April 2019
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
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