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Journal:FEBS Journal:1
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| - | Interleukin 24 (IL-24) is cytokine, member of Interleukin 10 family. It forms an IL-20 subfamily with IL-19, IL-20, IL-22 because all these interleukins use the common class II cytokine receptor subunits and have similarities in biological functions <ref name="Rutz">PMID:25421700</ref>. IL-24 signals via two heterodimeric receptor complexes IL-22R1/IL-20R2 and IL-20R1/IL-20R2 and activates the STAT3 and STAT1 signaling <ref name="Dumoutier">PMID:11564763</ref><ref name="Wang">PMID:15667561</ref> (see static image below). | + | Interleukin 24 (IL-24) is cytokine, member of Interleukin 10 family. It forms an IL-20 subfamily with IL-19, IL-20, IL-22 because all these interleukins use the common class II cytokine receptor subunits and have similarities in biological functions <ref name="Rutz">PMID:25421700</ref>. IL-24 signals via two heterodimeric receptor complexes IL-22R1/IL-20R2 and IL-20R1/IL-20R2 and activates the STAT3 and STAT1 signaling <ref name="Dumoutier">PMID:11564763</ref><ref name="Wang">PMID:15667561</ref> (see static image and 3D scenes below). |
[[Image:Figure_1febs.png|left|400px|thumb|Scheme of promiscuous binding of IL-20 and IL-24 to signaling receptors IL-20R1 and IL-22R1. Arrows indicate binding between cytokines and their receptors; thick arrows show preferential binding, dashed ones alternative binding to the promiscuous receptors.<ref name="Akdis">PMID:21377040</ref>]] | [[Image:Figure_1febs.png|left|400px|thumb|Scheme of promiscuous binding of IL-20 and IL-24 to signaling receptors IL-20R1 and IL-22R1. Arrows indicate binding between cytokines and their receptors; thick arrows show preferential binding, dashed ones alternative binding to the promiscuous receptors.<ref name="Akdis">PMID:21377040</ref>]] | ||
{{Clear}} | {{Clear}} | ||
| - | <scene name='81/818542/Cv/3'>3D representation of Type II ternary complex</scene> (PDB ID [[6df3]]<ref name="Lub">PMID:30111632</ref>). | + | *<scene name='81/818542/Cv/4'>3D representation of Type I ternary complex</scene> (PDB ID [[4doh]]) |
| + | *<scene name='81/818542/Cv/3'>3D representation of Type II ternary complex</scene> (PDB ID [[6df3]]<ref name="Lub">PMID:30111632</ref>). | ||
IL-24 is associated with multiple diseases, including the promotion and amplification of inflammatory responses during autoimmune and chronic inflammation <ref name="Rutz">PMID:25421700</ref>, psoriasis-like skin inflammation <ref name="Kumari">PMID:24211183</ref>, epidermal inflammation induced by stresses <ref name="Jin">PMID:25168428</ref>, inflammatory bowel disease <ref name="Andoh">PMID:19535621</ref><ref name="Fonseca-Camarillo">PMID:24527982</ref>, and also with host defense during bacterial infection <ref name="Ma">PMID:19830736</ref>. Some studies suggest anti-cancer activities that increased the interest in this molecule. | IL-24 is associated with multiple diseases, including the promotion and amplification of inflammatory responses during autoimmune and chronic inflammation <ref name="Rutz">PMID:25421700</ref>, psoriasis-like skin inflammation <ref name="Kumari">PMID:24211183</ref>, epidermal inflammation induced by stresses <ref name="Jin">PMID:25168428</ref>, inflammatory bowel disease <ref name="Andoh">PMID:19535621</ref><ref name="Fonseca-Camarillo">PMID:24527982</ref>, and also with host defense during bacterial infection <ref name="Ma">PMID:19830736</ref>. Some studies suggest anti-cancer activities that increased the interest in this molecule. | ||
Revision as of 12:22, 17 June 2019
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This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
