6hf6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Protease 1 (E29A,E60A,E80A) from Pyrococcus horikoshii co-crystallized with Tb-Xo4.== | |
| - | + | <StructureSection load='6hf6' size='340' side='right'caption='[[6hf6]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hf6]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HF6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MT:Tb-Xo4'>7MT</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=TB:TERBIUM(III)+ION'>TB</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hf6 OCA], [http://pdbe.org/6hf6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hf6 RCSB], [http://www.ebi.ac.uk/pdbsum/6hf6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hf6 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/DEGLY_PYRHO DEGLY_PYRHO]] Deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage (By similarity). Also displays proteolytic activity (PubMed:11114201).[UniProtKB:Q51732]<ref>PMID:11114201</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Breyton, C]] | ||
| + | [[Category: Engilberge, S]] | ||
| + | [[Category: Franzetti, B]] | ||
| + | [[Category: Girard, E]] | ||
[[Category: Maury, O]] | [[Category: Maury, O]] | ||
| - | [[Category: Girard, E]] | ||
[[Category: Riobe, F]] | [[Category: Riobe, F]] | ||
| - | [[Category: Breyton, C]] | ||
| - | [[Category: Franzetti, B]] | ||
[[Category: Santoni, G]] | [[Category: Santoni, G]] | ||
| - | [[Category: | + | [[Category: Shima, S]] |
| + | [[Category: Wagner, T]] | ||
| + | [[Category: Cccluster]] | ||
| + | [[Category: Crystallization]] | ||
| + | [[Category: Crystallophore]] | ||
| + | [[Category: De novo phasing]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lanthanide complex]] | ||
| + | [[Category: Meshandcollect]] | ||
| + | [[Category: Multi-crystals data collection]] | ||
| + | [[Category: Sad]] | ||
| + | [[Category: Tb-xo4]] | ||
Revision as of 05:54, 19 June 2019
Crystal structure of the Protease 1 (E29A,E60A,E80A) from Pyrococcus horikoshii co-crystallized with Tb-Xo4.
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Categories: Large Structures | Breyton, C | Engilberge, S | Franzetti, B | Girard, E | Maury, O | Riobe, F | Santoni, G | Shima, S | Wagner, T | Cccluster | Crystallization | Crystallophore | De novo phasing | Hydrolase | Lanthanide complex | Meshandcollect | Multi-crystals data collection | Sad | Tb-xo4
