Fatty acid synthase
From Proteopedia
(Difference between revisions)
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<scene name='48/484817/Cv/6'>Active site predominantly consists of hydrophobic/non-polar residues</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). The <scene name='48/484817/Cv/7'>long fatty acid ligand is nestled in a long groove and tunnel</scene><ref>PMID:21908709</ref>. | <scene name='48/484817/Cv/6'>Active site predominantly consists of hydrophobic/non-polar residues</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}). The <scene name='48/484817/Cv/7'>long fatty acid ligand is nestled in a long groove and tunnel</scene><ref>PMID:21908709</ref>. | ||
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| + | == 3D structures of fatty acid synthase== | ||
| + | [[Fatty acid synthase 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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*Fatty acid synthase | *Fatty acid synthase | ||
| - | **[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4v8w]] – MtFAS I – Cryo-EM<br /> | ||
| - | **[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br /> | ||
**[[1xkt]], [[4z49]] – hFAS thioesterase domain – human<br /> | **[[1xkt]], [[4z49]] – hFAS thioesterase domain – human<br /> | ||
**[[2jfd]] – hFAS MAT domain<br /> | **[[2jfd]] – hFAS MAT domain<br /> | ||
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**[[4w82]] – hFAS enoyl- ACP-reductase domain<br /> | **[[4w82]] – hFAS enoyl- ACP-reductase domain<br /> | ||
**[[2cf2]], [[2vz8]] – pFAS – pig<br /> | **[[2cf2]], [[2vz8]] – pFAS – pig<br /> | ||
| + | **[[2png]] – FAS ACP domain – rat<br /> | ||
| + | **[[5my2]] – FAS DI domain – mouse<br /> | ||
**[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br /> | **[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br /> | ||
**[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br /> | **[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br /> | ||
| - | **[[ | + | **[[6fn6]] – FAS – ''Drosophila melanogaster''<br /> |
| - | + | ||
**[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br /> | **[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br /> | ||
**[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR<br /> | **[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR<br /> | ||
| - | **[[ | + | **[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> |
| + | **[[4v8w]] – MtFAS I – Cryo-EM<br /> | ||
| + | **[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br /> | ||
| + | **[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br /> | ||
*FAS complex with fatty acid | *FAS complex with fatty acid | ||
| + | **[[3tjm]] – hFAS thioesterase domain + fatty acid<br /> | ||
| + | **[[2fae]] – EcFAS ACP domain + decanethioate<br /> | ||
| + | **[[2fad]] – EcFAS ACP domain + heptanthioate<br /> | ||
**[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br /> | **[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br /> | ||
**[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br /> | **[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br /> | ||
**[[1kpi]] – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br /> | **[[1kpi]] – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br /> | ||
**[[3hem]] - MtFAS CmaA1 + dioctylamine<br /> | **[[3hem]] - MtFAS CmaA1 + dioctylamine<br /> | ||
| - | **[[3tjm]] – hFAS thioesterase domain + fatty acid<br /> | ||
| - | **[[2fae]] – EcFAS ACP domain + decanethioate<br /> | ||
| - | **[[2fad]] – EcFAS ACP domain + heptanthioate | ||
*FAS complex with reactants | *FAS complex with reactants | ||
**[[2jfk]] – hFAS + malonyl CoA<br /> | **[[2jfk]] – hFAS + malonyl CoA<br /> | ||
| + | **[[2vz9]] – pFAS + NADP<BR /> | ||
**[[5my0]] - mFAS + malonyl CoA<br /> | **[[5my0]] - mFAS + malonyl CoA<br /> | ||
| - | **[[4v59]] – TlFAS + NADP<BR /> | ||
**[[2wat]] – yFAS α subunit + CoA<br /> | **[[2wat]] – yFAS α subunit + CoA<br /> | ||
| - | **[[ | + | **[[4v59]] – TlFAS + NADP<BR /> |
*FAS complex with protein | *FAS complex with protein | ||
| + | **[[2cg5]] - hFAS ACP domain + AASD-PPT<br /> | ||
**[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br /> | **[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br /> | ||
**[[3ejb]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme<br /> | **[[3ejb]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme<br /> | ||
**[[3ejb]], [[3eje]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid<br /> | **[[3ejb]], [[3eje]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid<br /> | ||
| - | **[[2cg5]] - hFAS ACP domain + AASD-PPT | ||
*FAS complex with inhibitor | *FAS complex with inhibitor | ||
| - | **[[2vkz]] - yFAS α+β subunits + cerulenin<br /> | ||
**[[2px6]] – hFAS thioesterase domain + orlistat<br /> | **[[2px6]] – hFAS thioesterase domain + orlistat<br /> | ||
| - | **[[4piv]], [[5c37]] – hFAS (mutant) + NADP + inhibitor<br /> | + | **[[4piv]], [[5c37]], [[6nna]] – hFAS (mutant) + NADP + inhibitor<br /> |
| + | **[[2vkz]] - yFAS α+β subunits + cerulenin<br /> | ||
}} | }} | ||
== References == | == References == | ||
Revision as of 09:20, 26 June 2019
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3D structures of fatty acid synthase
Updated on 26-June-2019
References
- ↑ Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res. 2003 Jul;42(4):289-317. PMID:12689621
- ↑ Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15757-62. Epub 2011 Sep 9. PMID:21908709 doi:10.1073/pnas.1112334108
