Fatty acid synthase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | == 3D structures of fatty acid synthase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Fatty acid synthase | ||
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| - | **[[1xkt]], [[4z49]] – hFAS thioesterase domain – human<br /> | ||
| - | **[[2jfd]] – hFAS MAT domain<br /> | ||
| - | **[[3hhd]] - hFAS KS-MAT domain<br /> | ||
| - | **[[4w82]] – hFAS enoyl- ACP-reductase domain<br /> | ||
| - | **[[2cf2]], [[2vz8]] – pFAS – pig<br /> | ||
| - | **[[2png]] – FAS ACP domain – rat<br /> | ||
| - | **[[5my2]] – FAS DI domain – mouse<br /> | ||
| - | **[[2uv8]], [[3hmj]] – yFAS α+β subunits - yeast<br /> | ||
| - | **[[2pff]], [[2was]], [[2ml8]] – yFAS α subunit<br /> | ||
| - | **[[6fn6]] – FAS – ''Drosophila melanogaster''<br /> | ||
| - | **[[1t8k]] – EcFAS ACP domain - ''Escherichia coli''<br /> | ||
| - | **[[2k92]], [[2k93]], [[2k94]] - EcFAS ACP domain – NMR<br /> | ||
| - | **[[1kp9]] – MtFAS CmaA1 – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[4v8w]] – MtFAS I – Cryo-EM<br /> | ||
| - | **[[4v8l]] – FAS – ''Mycobacterium smegmatis'' – Cryo-EM<br /> | ||
| - | **[[4v58]] – TlFAS – ''Thermomyces lanuginosus''<br /> | ||
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| - | *FAS complex with fatty acid | ||
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| - | **[[3tjm]] – hFAS thioesterase domain + fatty acid<br /> | ||
| - | **[[2fae]] – EcFAS ACP domain + decanethioate<br /> | ||
| - | **[[2fad]] – EcFAS ACP domain + heptanthioate<br /> | ||
| - | **[[1kpg]] – MtFAS CmaA1 + cetyl-trimethyl-ammonium + adenosyl homocysteine<br /> | ||
| - | **[[1kph]] – MtFAS CmaA1 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br /> | ||
| - | **[[1kpi]] – MtFAS CmaA2 + didecyl-dimethyl-ammonium + adenosyl homocysteine<br /> | ||
| - | **[[3hem]] - MtFAS CmaA1 + dioctylamine<br /> | ||
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| - | *FAS complex with reactants | ||
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| - | **[[2jfk]] – hFAS + malonyl CoA<br /> | ||
| - | **[[2vz9]] – pFAS + NADP<BR /> | ||
| - | **[[5my0]] - mFAS + malonyl CoA<br /> | ||
| - | **[[2wat]] – yFAS α subunit + CoA<br /> | ||
| - | **[[4v59]] – TlFAS + NADP<BR /> | ||
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| - | *FAS complex with protein | ||
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| - | **[[2cg5]] - hFAS ACP domain + AASD-PPT<br /> | ||
| - | **[[2fhs]] – EcFAS ACP domain + enoyl-ACP reductase <br /> | ||
| - | **[[3ejb]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme<br /> | ||
| - | **[[3ejb]], [[3eje]] - EcFAS ACP domain + biotin biosynthesis cytochrome P450-like enzyme + fatty acid<br /> | ||
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| - | *FAS complex with inhibitor | ||
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| - | **[[2px6]] – hFAS thioesterase domain + orlistat<br /> | ||
| - | **[[4piv]], [[5c37]], [[6nna]] – hFAS (mutant) + NADP + inhibitor<br /> | ||
| - | **[[2vkz]] - yFAS α+β subunits + cerulenin<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:21, 26 June 2019
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References
- ↑ Smith S, Witkowski A, Joshi AK. Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res. 2003 Jul;42(4):289-317. PMID:12689621
- ↑ Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid. Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15757-62. Epub 2011 Sep 9. PMID:21908709 doi:10.1073/pnas.1112334108
