GTPase KRas
From Proteopedia
(Difference between revisions)
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*<scene name='78/781207/Cv/8'>Mg coordination site</scene>. | *<scene name='78/781207/Cv/8'>Mg coordination site</scene>. | ||
*<scene name='78/781207/Cv/10'>GDP/Mg binding cleft</scene>. | *<scene name='78/781207/Cv/10'>GDP/Mg binding cleft</scene>. | ||
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| + | == 3D Structures of GTPase KRas == | ||
| + | [[GTPase KRas 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of GTPase KRas == | == 3D Structures of GTPase KRas == | ||
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**[[5uk9]] – hKRas + GCP + GDP – human <br /> | **[[5uk9]] – hKRas + GCP + GDP – human <br /> | ||
**[[5vq2]] – hKRas + GTP <br /> | **[[5vq2]] – hKRas + GTP <br /> | ||
| + | **[[6god]] – hKRas + GPPNP <br /> | ||
| + | **[[6goe]], [[6gof]], [[6gog]], [[6gom]] – hKRas (mutant) + GPPNP <br /> | ||
**[[5w22]], [[4obe]], [[4lpk]], [[5vq8]] – hKRas + GDP <br /> | **[[5w22]], [[4obe]], [[4lpk]], [[5vq8]] – hKRas + GDP <br /> | ||
**[[3gft]] – hKRas (mutant) + GTP analog <br /> | **[[3gft]] – hKRas (mutant) + GTP analog <br /> | ||
| - | **[[4l8g]], [[4ldj]], [[4ql3]], [[4tq9]], [[4tqa]], [[6asa]], [[6ase]], [[5whd]], [[5uqw]], [[5us4]], [[5vp7]], [[5vq0]], [[5vq1]], [[4wa7]], [[4lrw]] – hKRas (mutant) + GDP <br /> | + | **[[4l8g]], [[4ldj]], [[4ql3]], [[4tq9]], [[4tqa]], [[6asa]], [[6ase]], [[5whd]], [[5uqw]], [[5us4]], [[5vp7]], [[5vq0]], [[5vq1]], [[4wa7]], [[4lrw]], [[6bof]] – hKRas (mutant) + GDP <br /> |
**[[5vpi]], [[5vpz]], [[5vq6]] – hKRas (mutant) + GTP <br /> | **[[5vpi]], [[5vpz]], [[5vq6]] – hKRas (mutant) + GTP <br /> | ||
**[[5usj]], [[5vpy]] – hKRas (mutant) + GNP <br /> | **[[5usj]], [[5vpy]] – hKRas (mutant) + GNP <br /> | ||
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**[[5kyk]] – hKRas + inhibitor <br /> | **[[5kyk]] – hKRas + inhibitor <br /> | ||
**[[4nmm]] – hKRas (mutant) + inhibitor <br /> | **[[4nmm]] – hKRas (mutant) + inhibitor <br /> | ||
| - | **[[5v9o]], [[5f2e]], [[5v9u]], [[4dsu]], [[4luc]], [[4lv6]], [[4lyf]], [[4lyh]], [[4lyj]], [[4m1o]], [[4m1s]], [[4m1t]], [[4m1w]], [[4m1y]], [[4m21]], [[4m22]], [[4epr]], [[4ept]], [[4epv]], [[4epw]], [[4epx]], [[4epy]], [[4q01]], [[4q02]], [[4q03]], [[5vbm]], [[5v6s]], [[5v6v]], [[6ark]], [[5xco]], [[6b0v]], [[6b0y]], [[5yxz]], [[5yy1]], [[4pzy]], [[4pzz]] – hKRas (mutant) + GDP + inhibitor <br /> | + | **[[5v9o]], [[5f2e]], [[5v9u]], [[4dsu]], [[4luc]], [[4lv6]], [[4lyf]], [[4lyh]], [[4lyj]], [[4m1o]], [[4m1s]], [[4m1t]], [[4m1w]], [[4m1y]], [[4m21]], [[4m22]], [[4epr]], [[4ept]], [[4epv]], [[4epw]], [[4epx]], [[4epy]], [[4q01]], [[4q02]], [[4q03]], [[5vbm]], [[5v6s]], [[5v6v]], [[6ark]], [[5xco]], [[6b0v]], [[6b0y]], [[5yxz]], [[5yy1]], [[4pzy]], [[4pzz]], [[6n2j]], [[6n2k]] – hKRas (mutant) + GDP + inhibitor <br /> |
| - | **[[5vbz]] – hKRas (mutant) + GNP + inhibitor <br /> | + | **[[5vbz]], [[6gqy]], [[6gqw]], [[6gqx]], [[6gqt]] – hKRas (mutant) + GNP + inhibitor <br /> |
| + | **[[6fa1]], [[6fa2]], [[6fa3]], [[6fa4]], [[5oct]], [[5oco]], [[5ocg]] – hKRas (mutant) + GNP + inhibitor<br /> | ||
| + | **[[6f76]] – hKRas (mutant) + GPPNP + inhibitor<br /> | ||
**[[5v71]], [[5v9l]] – hKRas (mutant) + GDP + quinazoline inhibitor <br /> | **[[5v71]], [[5v9l]] – hKRas (mutant) + GDP + quinazoline inhibitor <br /> | ||
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**[[5wha]], [[5whb]] – hKRas (mutant) + miniprotein + GDP <br /> | **[[5wha]], [[5whb]] – hKRas (mutant) + miniprotein + GDP <br /> | ||
**[[5wpl]], [[5whe]], [[5wpm]], [[5wlb]] – hKRas (mutant) + miniprotein + GNP <br /> | **[[5wpl]], [[5whe]], [[5wpm]], [[5wlb]] – hKRas (mutant) + miniprotein + GNP <br /> | ||
| + | **[[6h46]] – hKRas + darpin K13 + GDP <br /> | ||
| + | **[[6h47]] – hKRas + darpin K19 <br /> | ||
**[[5o2s]], [[5mlb]] – hKRas + darpin K27 + GDP <br /> | **[[5o2s]], [[5mlb]] – hKRas + darpin K27 + GDP <br /> | ||
**[[5tb5]], [[5tar]] – hKRas + GMP-PDE d + farnesyl + GDP <br /> | **[[5tb5]], [[5tar]] – hKRas + GMP-PDE d + farnesyl + GDP <br /> | ||
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**[[2msc]], [[2msd]] – hKRas + apolipoprotein + GDP - NMR<br /> | **[[2msc]], [[2msd]] – hKRas + apolipoprotein + GDP - NMR<br /> | ||
**[[2mse]] – hKRas + apolipoprotein + A-Raf + GDP - NMR<br /> | **[[2mse]] – hKRas + apolipoprotein + A-Raf + GDP - NMR<br /> | ||
| + | **[[6ccx]], [[6cch]], [[6cc9]] – hKRas (mutant) + apolipoprotein + inhibitor + GPPNP - NMR<br /> | ||
| + | **[[6epl]] – hKRas (mutant) + son of sevenless homolog 1<br /> | ||
| + | **[[6epm]], [[6epn]], [[6epo]], [[6epp]] – hKRas (mutant) + son of sevenless homolog 1 + inhibitor<br /> | ||
}} | }} | ||
Revision as of 07:30, 21 July 2019
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3D Structures of GTPase KRas
Updated on 21-July-2019
References
- ↑ Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science. 1990 Feb 23;247(4945):939-45. PMID:2406906
- ↑ Shibata H, Ohike N, Norose T, Isobe T, Suzuki R, Imai H, Shiokawa A, Aoki T, Murakami M, Mizukami H, Tanaka JI, Takimoto M. Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. Anticancer Res. 2017 Dec;37(12):7063-7068. doi: 10.21873/anticanres.12178. PMID:29187496 doi:http://dx.doi.org/10.21873/anticanres.12178
- ↑ Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew Chem Int Ed Engl. 2012 May 8. doi: 10.1002/anie.201201358. PMID:22566140 doi:10.1002/anie.201201358
