GTPase KRas
From Proteopedia
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| - | == 3D Structures of GTPase KRas == | ||
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| - | *GTPase KRas | ||
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| - | **[[5uk9]] – hKRas + GCP + GDP – human <br /> | ||
| - | **[[5vq2]] – hKRas + GTP <br /> | ||
| - | **[[6god]] – hKRas + GPPNP <br /> | ||
| - | **[[6goe]], [[6gof]], [[6gog]], [[6gom]] – hKRas (mutant) + GPPNP <br /> | ||
| - | **[[5w22]], [[4obe]], [[4lpk]], [[5vq8]] – hKRas + GDP <br /> | ||
| - | **[[3gft]] – hKRas (mutant) + GTP analog <br /> | ||
| - | **[[4l8g]], [[4ldj]], [[4ql3]], [[4tq9]], [[4tqa]], [[6asa]], [[6ase]], [[5whd]], [[5uqw]], [[5us4]], [[5vp7]], [[5vq0]], [[5vq1]], [[4wa7]], [[4lrw]], [[6bof]] – hKRas (mutant) + GDP <br /> | ||
| - | **[[5vpi]], [[5vpz]], [[5vq6]] – hKRas (mutant) + GTP <br /> | ||
| - | **[[5usj]], [[5vpy]] – hKRas (mutant) + GNP <br /> | ||
| - | **[[6bp1]], [[4dsn]] – hKRas (mutant) + GCP <br /> | ||
| - | **[[4dso]] – hKRas (mutant) + inhibitor + GSP <br /> | ||
| - | **[[4dst]] – hKRas (mutant) + inhibitor + GCP <br /> | ||
| - | **[[5kyk]] – hKRas + inhibitor <br /> | ||
| - | **[[4nmm]] – hKRas (mutant) + inhibitor <br /> | ||
| - | **[[5v9o]], [[5f2e]], [[5v9u]], [[4dsu]], [[4luc]], [[4lv6]], [[4lyf]], [[4lyh]], [[4lyj]], [[4m1o]], [[4m1s]], [[4m1t]], [[4m1w]], [[4m1y]], [[4m21]], [[4m22]], [[4epr]], [[4ept]], [[4epv]], [[4epw]], [[4epx]], [[4epy]], [[4q01]], [[4q02]], [[4q03]], [[5vbm]], [[5v6s]], [[5v6v]], [[6ark]], [[5xco]], [[6b0v]], [[6b0y]], [[5yxz]], [[5yy1]], [[4pzy]], [[4pzz]], [[6n2j]], [[6n2k]] – hKRas (mutant) + GDP + inhibitor <br /> | ||
| - | **[[5vbz]], [[6gqy]], [[6gqw]], [[6gqx]], [[6gqt]] – hKRas (mutant) + GNP + inhibitor <br /> | ||
| - | **[[6fa1]], [[6fa2]], [[6fa3]], [[6fa4]], [[5oct]], [[5oco]], [[5ocg]] – hKRas (mutant) + GNP + inhibitor<br /> | ||
| - | **[[6f76]] – hKRas (mutant) + GPPNP + inhibitor<br /> | ||
| - | **[[5v71]], [[5v9l]] – hKRas (mutant) + GDP + quinazoline inhibitor <br /> | ||
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| - | *GTPase KRas complex with protein | ||
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| - | **[[5wha]], [[5whb]] – hKRas (mutant) + miniprotein + GDP <br /> | ||
| - | **[[5wpl]], [[5whe]], [[5wpm]], [[5wlb]] – hKRas (mutant) + miniprotein + GNP <br /> | ||
| - | **[[6h46]] – hKRas + darpin K13 + GDP <br /> | ||
| - | **[[6h47]] – hKRas + darpin K19 <br /> | ||
| - | **[[5o2s]], [[5mlb]] – hKRas + darpin K27 + GDP <br /> | ||
| - | **[[5tb5]], [[5tar]] – hKRas + GMP-PDE d + farnesyl + GDP <br /> | ||
| - | **[[5o2t]], [[5mla]] – hKRas + darpin 55 + GSP <br /> | ||
| - | **[[5ufe]] – hKRas + R11.1.6 + GNP <br /> | ||
| - | **[[5ufq]] – hKRas (mutant) + R11.1.6 + GNP <br /> | ||
| - | **[[2msc]], [[2msd]] – hKRas + apolipoprotein + GDP - NMR<br /> | ||
| - | **[[2mse]] – hKRas + apolipoprotein + A-Raf + GDP - NMR<br /> | ||
| - | **[[6ccx]], [[6cch]], [[6cc9]] – hKRas (mutant) + apolipoprotein + inhibitor + GPPNP - NMR<br /> | ||
| - | **[[6epl]] – hKRas (mutant) + son of sevenless homolog 1<br /> | ||
| - | **[[6epm]], [[6epn]], [[6epo]], [[6epp]] – hKRas (mutant) + son of sevenless homolog 1 + inhibitor<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 07:31, 21 July 2019
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References
- ↑ Milburn MV, Tong L, deVos AM, Brunger A, Yamaizumi Z, Nishimura S, Kim SH. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science. 1990 Feb 23;247(4945):939-45. PMID:2406906
- ↑ Shibata H, Ohike N, Norose T, Isobe T, Suzuki R, Imai H, Shiokawa A, Aoki T, Murakami M, Mizukami H, Tanaka JI, Takimoto M. Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. Anticancer Res. 2017 Dec;37(12):7063-7068. doi: 10.21873/anticanres.12178. PMID:29187496 doi:http://dx.doi.org/10.21873/anticanres.12178
- ↑ Sun Q, Burke JP, Phan J, Burns MC, Olejniczak ET, Waterson AG, Lee T, Rossanese OW, Fesik SW. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew Chem Int Ed Engl. 2012 May 8. doi: 10.1002/anie.201201358. PMID:22566140 doi:10.1002/anie.201201358
