Rho GTPase activating protein

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Revision as of 13:22, 26 August 2019

Human RhoGAP 1 (magenta) complex with RhoA (blue), GDP, MgF3 and Mg+2 ions (PDB code 1ow3)

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Updated on 26-August-2019

↑ Moon SY, Zheng Y. Rho GTPase-activating proteins in cell regulation. Trends Cell Biol. 2003 Jan;13(1):13-22. PMID:12480336
↑ Kandpal RP. Rho GTPase activating proteins in cancer phenotypes. Curr Protein Pept Sci. 2006 Aug;7(4):355-65. PMID:16918449
↑ Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF. MgF(3)(-) as a transition state analog of phosphoryl transfer. Chem Biol. 2002 Mar;9(3):375-81. PMID:11927263

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	== Structural highlights ==		== Structural highlights ==
-	The <scene name='75/750307/Cv/3'>active site of RhoGAP</scene> contains a <scene name='75/750307/Cv/4'>catalytic arginine</scene> and GDP<ref>PMID:11927263</ref>. Water molecules shown as red spheres. <scene name='75/750307/Cv/4'>Mg/MgF3 coordination site</scene>.	+	The <scene name='75/750307/Cv/6'>active site of RhoGAP</scene> contains a <scene name='75/750307/Cv/7'>catalytic arginine</scene> and GDP<ref>PMID:11927263</ref>. Water molecules are shown as red spheres. <scene name='75/750307/Cv/8'>Mg/MgF3 coordination site</scene>.