Isocitrate dehydrogenase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 47: Line 47:
* [[Cancer]]
* [[Cancer]]
* [[Krebs cycle step 3]]
* [[Krebs cycle step 3]]
 +
 +
==3D Structures of Isocitrate dehydrogenase==
 +
[[Isocitrate dehydrogenase 3D structures]]
 +
</StructureSection>
</StructureSection>
Line 56: Line 60:
*Isocitrate dehydrogenase
*Isocitrate dehydrogenase
-
**[[3blx]] – hIDH - yeast<br />
+
**[[5grh]] – hIDH3 α,γ subunits + Mg - human<br />
 +
**[[3blx]] – yIDH - yeast<br />
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
**[[3dms]] – IDH – ''Burkholderia pseudomallei''<br />
**[[3dms]] – IDH – ''Burkholderia pseudomallei''<br />
Line 69: Line 74:
**[[3us8]] – IDH – ''Sinorhizobium meliloti''<br />
**[[3us8]] – IDH – ''Sinorhizobium meliloti''<br />
**[[4aoy]] – CtIDH – ''Clostridium thermocellum''<br />
**[[4aoy]] – CtIDH – ''Clostridium thermocellum''<br />
-
**[[5grh]] – hIDH3 α,γ subunits + Mg - human<br />
+
**[[5z16]] – IDH –'' Acinetobacter baumannii''<br />
 +
**[[5m2e]] - PaIDH – ''Pseudomonas aeruginosa''<br />
*IDH+citrate
*IDH+citrate
 +
**[[5yfn]] – hIDH1 + isocitrate+ Mg<br />
 +
**[[5gri]] – hIDH3 a,g subunits + citrate+ Mg<br />
**[[2qfw]] – yIDH+isocitrate <br />
**[[2qfw]] – yIDH+isocitrate <br />
**[[3blv]] – yIDH+citrate<br />
**[[3blv]] – yIDH+citrate<br />
Line 84: Line 92:
**[[1hqs]] – IDH+citrate – ''Bacillus subtilis''<br />
**[[1hqs]] – IDH+citrate – ''Bacillus subtilis''<br />
**[[4zda]] - IDH +isocitrate+Mn – ''Mycobacterium smegmatis''<br />
**[[4zda]] - IDH +isocitrate+Mn – ''Mycobacterium smegmatis''<br />
-
**[[5gri]] – hIDH3 α,γ subunits + citrate+ Mg<br />
 
*IDH+NADP
*IDH+NADP
Line 93: Line 100:
**[[5svn]], [[5svo]] – hIDH2 (mutant) + NADP<br />
**[[5svn]], [[5svo]] – hIDH2 (mutant) + NADP<br />
**[[5yvt]] – hIDH α+γ + NADH<br />
**[[5yvt]] – hIDH α+γ + NADH<br />
 +
**[[5yzh]] – mIDH+NADP – mouse<br />
**[[2qfv]] – yIDH+NADP <br />
**[[2qfv]] – yIDH+NADP <br />
**[[2e5m]] – StIDH+NADP <br />
**[[2e5m]] – StIDH+NADP <br />
-
**[[5yzh]] – mIDH+NADP – mouse<br />
 
**[[1tyo]] - ApIDH+NADP<br />
**[[1tyo]] - ApIDH+NADP<br />
**[[1j1w]] – AvIDH+NADP – ''Azotobacter vinelandii''<br />
**[[1j1w]] – AvIDH+NADP – ''Azotobacter vinelandii''<br />
Line 102: Line 109:
**[[3mbc]] - IDH (mutant)+NADP – ''Corynebacterium glutamicum''<br />
**[[3mbc]] - IDH (mutant)+NADP – ''Corynebacterium glutamicum''<br />
**[[4hcx]], [[5kvu]] – IDH + NADP – ''mycobacterium tuberculosis''<br />
**[[4hcx]], [[5kvu]] – IDH + NADP – ''mycobacterium tuberculosis''<br />
 +
**[[6aj6]] – TbIDH (mutant) + NADP – ''Trypanosoma brucei''<br />
*IDH+α-ketoglutarate
*IDH+α-ketoglutarate
 +
**[[3inm]], [[4l03]], [[4l04]], [[4l06]], [[5i95]] – hIDH1 (mutant)+NADPH+α-ketoglutarate+Ca <br />
 +
**[[4kzo]] - hIDH1 +NADPH+α-ketoglutarate+Ca<br />
**[[2qfy]] - yIDH+α-ketoglutarate<br />
**[[2qfy]] - yIDH+α-ketoglutarate<br />
 +
**[[2qfx]] - yIDH+NADPH+α-ketoglutarate+Ca<br />
**[[1cw4]] – EcIDH (mutant)+α-ketoglutarate<br />
**[[1cw4]] – EcIDH (mutant)+α-ketoglutarate<br />
**[[1ika]] - EcIDH + α-ketoglutarate+Ca<br />
**[[1ika]] - EcIDH + α-ketoglutarate+Ca<br />
-
**[[3inm]], [[4l03]], [[4l04]], [[4l06]], [[5i95]] – hIDH (mutant)+NADPH+α-ketoglutarate+Ca <br />
 
-
**[[4kzo]] - hIDH +NADPH+α-ketoglutarate+Ca<br />
 
-
**[[2qfx]] - yIDH+NADPH+α-ketoglutarate+Ca<br />
 
**[[4ajc]] - EcIDH (mutant) +α-ketoglutarate+A2P+Ca<br />
**[[4ajc]] - EcIDH (mutant) +α-ketoglutarate+A2P+Ca<br />
**[[4ajr]] - EcIDH (mutant) +α-ketoglutarate+ NADP+ Mg<br />
**[[4ajr]] - EcIDH (mutant) +α-ketoglutarate+ NADP+ Mg<br />
**[[1bl5]] - EcIDH +α-ketoglutarate+NADP+Mg<br />
**[[1bl5]] - EcIDH +α-ketoglutarate+NADP+Mg<br />
**[[6c0e]] - IDH +NADPH+ α-ketoglutarate – ''Legionella pneumophila''<br />
**[[6c0e]] - IDH +NADPH+ α-ketoglutarate – ''Legionella pneumophila''<br />
 +
**[[6g3u]] - PaIDH +NADPH+ α-ketoglutarate <br />
 +
**[[6aj8]], [[6aja]], [[6ajb]] - TbIDH (mutant) +NADP + α-ketoglutarate <br />
*IDH binary complex
*IDH binary complex
-
**[[3asj]] – TtIDH + inhbibitor<br />
+
**[[5yfm]] – hIDH1 + isocitrate<br />
-
**[[5yfm]] – hIDH + isocitrate<br />
+
**[[5h3f]] – mIDH 2 + isocitrate<br />
**[[5h3f]] – mIDH 2 + isocitrate<br />
**[[5h3e]] – mIDH 2 (mutant) + isocitrate<br />
**[[5h3e]] – mIDH 2 (mutant) + isocitrate<br />
 +
**[[3asj]] – TtIDH + inhbibitor<br />
*IDH higher complexes
*IDH higher complexes
Line 131: Line 141:
**[[5grl]] – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg<br />
**[[5grl]] – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg<br />
**[[5l57]], [[5l58]] - hIDH +NADP + inhibitor<br />
**[[5l57]], [[5l58]] - hIDH +NADP + inhibitor<br />
-
**[[4i3k]], [[4i3l]], [[4ja8]],[[4umx]], [[4umy]], [[4xrx]], [[4xs3]], [[5de1]], [[5lge]], [[5sun]], [[5svf]], [[6b0z]], [[5tqh]] - hIDH (mutant) +NADP + inhibitor<br />
+
**[[4i3k]], [[4i3l]], [[4ja8]],[[4umx]], [[4umy]], [[4xrx]], [[4xs3]], [[5de1]], [[5lge]], [[5sun]], [[5svf]], [[6b0z]], [[5tqh]], [[6o2y]], [[6o2z]], [[6adg]] - hIDH1 (mutant) +NADP + inhibitor<br />
 +
**[[6adi]] – hIDH2 (mutant) +NADP + inhibitor<br />
 +
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] - hIDH + isocitrate + inhibitor<br />
**[[5svf]] - hIDH (mutant) +NADP + citrate + inhibitor<br />
**[[5svf]] - hIDH (mutant) +NADP + citrate + inhibitor<br />
-
**[[5i96]] – hIDH + NADP+ enasidenib + Ca<br />
+
**[[5i96]] – hIDH2 + NADP+ enasidenib + Ca<br />
-
**[[3blw]] – yIDH+citrate+AMP<br />
+
**[[5yzi]] - mIDH+NADP+citrate<br />
**[[5yzi]] - mIDH+NADP+citrate<br />
 +
**[[3blw]] – yIDH+citrate+AMP<br />
**[[2d4v]] – IDH+NAD+citrate – ''Acidithiobacillus thiooxidans''<br />
**[[2d4v]] – IDH+NAD+citrate – ''Acidithiobacillus thiooxidans''<br />
**[[2d1c]] – TtIDH+NADP+citrate <br />
**[[2d1c]] – TtIDH+NADP+citrate <br />
**[[1xkd]] – ApIDH+NADP+citrate <br />
**[[1xkd]] – ApIDH+NADP+citrate <br />
-
**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
 
**[[1idc]] - EcIDH (mutant)+oxalosuccinate+Mg<br />
**[[1idc]] - EcIDH (mutant)+oxalosuccinate+Mg<br />
 +
**[[6ajc]] - TbIDH (mutant) +NADP+isocitrate<br />
 +
 +
*IDH quaternary complexes
 +
 +
**[[5svf]] – hIDH1 (mutant) +NADP + citrate + inhibitor<br />
 +
**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
**[[1ai2]], [[4aj3]], [[4aja]] - EcIDH +isocitrate+NADP+Ca<br />
**[[1ai2]], [[4aj3]], [[4aja]] - EcIDH +isocitrate+NADP+Ca<br />
Line 149: Line 166:
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
**[[4aov]] - DpIDH + isocitrate+NADP+Mg
**[[4aov]] - DpIDH + isocitrate+NADP+Mg
 +
}}
}}
=='''References'''==
=='''References'''==

Revision as of 10:04, 5 September 2019

Isocitrate dehydrogenase dimer complex with isocitrate, glycerol and Mg+2 ion (green) (PDB code 2uxr)

Drag the structure with the mouse to rotate

3D Structures of Isocitrate dehydrogenase

Updated on 05-September-2019

References

  1. ↑ Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004 Aug 6;279(32):33946-57. Epub 2004 Jun 1. PMID:15173171 doi:10.1074/jbc.M404298200
  2. ↑ Fedoy AE, Yang N, Martinez A, Leiros HK, Steen IH. Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability. J Mol Biol. 2007 Sep 7;372(1):130-49. Epub 2007 Jun 19. PMID:17632124 doi:10.1016/j.jmb.2007.06.040
  3. ↑ http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase#cite_note-nfr154197.2F32-6
  4. ↑ Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004 Aug 6;279(32):33946-57. Epub 2004 Jun 1. PMID:15173171 doi:10.1074/jbc.M404298200
  5. ↑ Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004 Aug 6;279(32):33946-57. Epub 2004 Jun 1. PMID:15173171 doi:10.1074/jbc.M404298200
  6. ↑ http://en.wikipedia.org/wiki/File:IDHcatalyticmechanism.jpg
  7. ↑ Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Lowenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010 Dec 14;18(6):553-67. Epub 2010 Dec 9. PMID:21130701 doi:10.1016/j.ccr.2010.11.015
Retrieved from "http://52.214.119.220/wiki/index.php/Isocitrate_dehydrogenase"
Personal tools