Proteasome

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*<scene name='41/417543/Cv/6'>Salinosporamide derivative binding site</scene> of chain H.
*<scene name='41/417543/Cv/6'>Salinosporamide derivative binding site</scene> of chain H.
*<scene name='41/417543/Cv/7'>Covalent bond between Salinosporamide derivative and Thr1</scene>.
*<scene name='41/417543/Cv/7'>Covalent bond between Salinosporamide derivative and Thr1</scene>.
 +
 +
== 3D Structures of Proteasome ==
 +
[[Proteasome 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of Proteasome ==
== 3D Structures of Proteasome ==
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* Proteasome 20S core
* Proteasome 20S core
-
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
 
-
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
 
-
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
 
-
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[5fg7]], [[5fg9]], [[5fga]] - y20S core (mutant)<br />
 
**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />
**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br />
 +
**[[1iru]] – 20S core - bovine<br />
 +
**[[3une]] – m20S core – mouse<br />
 +
**[[3unh]] – m20S core (immuno)<br />
 +
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br />
 +
**[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]] - y20S core (mutant)<br />
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br />
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**[[1q5q]] - Re20S core<br />
**[[1q5q]] - Re20S core<br />
**[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br />
**[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br />
-
**[[1iru]] – 20S core - bovine<br />
+
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br />
-
**[[3une]] – m20S core – mouse<br />
+
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br />
-
**[[3unh]] – m20S core (immuno)
+
*Proteasome 20S+activator protein
*Proteasome 20S+activator protein
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*Proteasome 20S+inhibitor
*Proteasome 20S+inhibitor
 +
**[[4r67]] – h20S + cancer drug<br />
 +
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br />
 +
**[[5a0q]] - h20S + substrate analog<br />
 +
**[[6avo]] – h20S core + inhibitor<br />
 +
**[[3unb]], [[3unf]] – m20S + inhibitor<br />
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]] – y20S core+inhibitor<br />
**[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]] – y20S core+inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br />
**[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br />
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**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br />
**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[5d0z]], [[5d0x]], [[5d0v]], [[5d0s]], [[5cz5]], [[5bxn]] - y20S (mutant) + cancer drug<br />
**[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[5d0z]], [[5d0x]], [[5d0v]], [[5d0s]], [[5cz5]], [[5bxn]] - y20S (mutant) + cancer drug<br />
-
**[[4r67]] – h20S + cancer drug<br />
 
**[[4x6z]] - y20S + modulator<br />
**[[4x6z]] - y20S + modulator<br />
**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br />
**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br />
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**[[5l65]], [[5l66]] - y20S + m20S beta5i + m20S beta6 + cancer drug<br />
**[[5l65]], [[5l66]] - y20S + m20S beta5i + m20S beta6 + cancer drug<br />
**[[5l67]], [[5l6b]] - y20S + m20S beta5i + m20S beta6 + inhibitor<br />
**[[5l67]], [[5l6b]] - y20S + m20S beta5i + m20S beta6 + inhibitor<br />
-
**[[3unb]], [[3unf]] – m20S + inhibitor<br />
 
-
**[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br />
 
-
**[[5a0q]] - h20S + substrate analog<br />
 
-
**[[6avo]] – h20S core + inhibitor<br />
 
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />
**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br />
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br />
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* Proteasome partial 20S particle
* Proteasome partial 20S particle
 +
**[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain<br />
**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />
**[[2ku1]], [[2ku2]] – Taa-PRTS chains A-G <br />
**[[3fp9]] – MtATPase chains A-L<br />
**[[3fp9]] – MtATPase chains A-L<br />
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**[[2jay]] – MtPRTS β subunit<br />
**[[2jay]] – MtPRTS β subunit<br />
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />
**[[5nyw]] – PRTS β subunit – ''Yersinia bercovieri''<br />
-
**[[2kqz]], [[2kr0]] – hPRTS ubiquitin receptor domain
 
*Proteasome partial 26S particle
*Proteasome partial 26S particle
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**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br />
**[[2dvw]], [[2dwz]] - mPRTS subunit 10 + hPRTS subunit 6B – mouse<br />
**[[3aji]] - mPRTS subunit 10 + subunit 4<br />
**[[3aji]] - mPRTS subunit 10 + subunit 4<br />
 +
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br />
**[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br />
**[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br />
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**[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br />
**[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br />
**[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /
**[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br /
-
**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br />
 
**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br />
**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br />
**[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br />
**[[5ubp]] - yPRTS subunit SEM1 + nuclear mRNA export protein THP1 + leucine permease transcriptional regulator<br />
 +
*Proteasome 26S particle
*Proteasome 26S particle
 +
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]], [[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] - hPRTS - Cryo EM<br />
 +
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
 +
**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – PRTS – rat - Cryo EM<br />
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]] – yPRTS – Cryo EM<br />
**[[3j47]], [[4cr2]], [[4cr3]], [[4cr4]], [[5wvi]], [[5mpc]] – yPRTS – Cryo EM<br />
**[[5wvk]] - yPRTS + ADP - Cryo EM<br />
**[[5wvk]] - yPRTS + ADP - Cryo EM<br />
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**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br />
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br />
-
**[[5l4g]], [[5gjr]], [[5ln3]], [[5t0c]], [[5t0g]], [[5t0h]], [[5t0i]], [[5t0j]] - hPRTS - Cryo EM<br />
 
-
**[[5m32]] - hPRTS + inhibitor - Cryo EM<br />
 
-
**[[6epf]], [[6epe]], [[6epd]], [[6epc]] – PRTS – rat - Cryo EM<br />
 
-
**[[5vhs]], [[5vhr]], [[5vhq]], [[5vhp]], [[5vho]], [[5vhn]], [[5vhm]], [[5vhj]], [[5vhi]], [[5vhh]], [[5vhf]], [[5vgz]], [[5vft]], [[5vfr]], [[5vfo]] – hPRTS - Cryo EM<br />
 
}}
}}

Revision as of 08:56, 28 November 2019

Yeast proteasome 20S core complex with salinosporamide derivative, 3gpt

Drag the structure with the mouse to rotate

3D Structures of Proteasome

Updated on 28-November-2019

References

  1. ↑ Saeki Y, Tanaka K. Assembly and function of the proteasome. Methods Mol Biol. 2012;832:315-37. doi: 10.1007/978-1-61779-474-2_22. PMID:22350895 doi:http://dx.doi.org/10.1007/978-1-61779-474-2_22
  2. ↑ Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PMID:8811196 doi:http://dx.doi.org/10.1146/annurev.bi.65.070196.004101

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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