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Proteasome
From Proteopedia
(Difference between revisions)
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**[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br /> | **[[4r3o]], [[5le5]], [[5lex]] – h20S core – human<br /> | ||
| + | **[[6rgq]], [[6r70]] – h20S core – Cryo EM<br /> | ||
**[[1iru]] – 20S core - bovine<br /> | **[[1iru]] – 20S core - bovine<br /> | ||
**[[3une]] – m20S core – mouse<br /> | **[[3une]] – m20S core – mouse<br /> | ||
**[[3unh]] – m20S core (immuno)<br /> | **[[3unh]] – m20S core (immuno)<br /> | ||
**[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br /> | **[[3gpt]], [[3gpw]], [[1g0u]], [[5cz4]] – y20S core - yeast<br /> | ||
| - | **[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]] - y20S core (mutant)<br /> | + | **[[1ryp]], [[3wxr]], [[4qux]], [[4quy]], [[4qv0]], [[4qv1]], [[4qv3]], [[4qv4]], [[4qv5]], [[4qv6]], [[4qv7]], [[4qv8]], [[4qv9]], [[4y8r]], [[4y9y]], [[4ya1]], [[4ya4]], [[5bxl]], [[5cgf]], [[5cza]], [[5d0w]], [[6hwc]] - y20S core (mutant)<br /> |
**[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br /> | **[[3c91]], [[3c92]], [[1pma]], [[3j9i]], [[5vy3]], [[6bdf]], [[5vy4]] – Ta20S core - ''Themoplasma acidophilum'' - Cryo EM<br /> | ||
**[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | **[[3h4p]] – 20S core – ''Methanocaldococcus janaschii''<br /> | ||
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**[[1q5q]] - Re20S core<br /> | **[[1q5q]] - Re20S core<br /> | ||
**[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br /> | **[[1j2q]] – Af20S core - ''Archaeoglobus fulgidus''<br /> | ||
| + | **[[6he7]] – Af20S - Cryo EM<br /> | ||
| + | **[[6qm8]] – Lt20S core – ''Leishmania tarentolae'' - Cryo EM<br /> | ||
| + | **[[6muw]] – Pf20S – ''Plasmodium falciparum'' - Cryo EM<br /> | ||
**[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | **[[3mfe]], [[3mi0]], [[2fhg]] – Mt20S core – ''Mycobacterium tuberculosis''<br /> | ||
**[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | **[[3mka]], [[3hfa]] – Mt20S core (mutant)<br /> | ||
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*Proteasome 20S+activator protein | *Proteasome 20S+activator protein | ||
| + | **[[6rey]] – h20S + activator PA200 – Cryo EM<br /> | ||
**[[4v7o]], [[5nif]] – y20S core+ Blm10 <br /> | **[[4v7o]], [[5nif]] – y20S core+ Blm10 <br /> | ||
**[[1z7q]], [[1fnt]] – y20S core+PA26<br /> | **[[1z7q]], [[1fnt]] – y20S core+PA26<br /> | ||
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**[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br /> | **[[5lzp]] - Mt20S subunits a+b + BPA - Cryo EM<br /> | ||
**[[6bgo]], [[6bgl]] – Mt20S + activator<br /> | **[[6bgo]], [[6bgl]] – Mt20S + activator<br /> | ||
| + | **[[6mux]], [[6muv]] – Pf20S + activator PA28 - Cryo EM<br /> | ||
| + | **[[6hed]], [[6hec]], [[6hea]], [[6he9]], [[6he8]], [[6he5]] – Af20S + PAN – Cryo EM<br /> | ||
*Proteasome 20S+inhibitor | *Proteasome 20S+inhibitor | ||
**[[4r67]] – h20S + cancer drug<br /> | **[[4r67]] – h20S + cancer drug<br /> | ||
| - | **[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]] - h20S + inhibitor<br /> | + | **[[5ley]], [[5lf0]], [[5lf1]], [[5lf3]], [[5lf4]], [[5lf7]], [[5lez]], [[5lf6]], [[6avo]], [[6e5b]] - h20S + inhibitor<br /> |
**[[5a0q]] - h20S + substrate analog<br /> | **[[5a0q]] - h20S + substrate analog<br /> | ||
| - | **[[6avo]] – h20S core + inhibitor<br /> | ||
**[[3unb]], [[3unf]] – m20S + inhibitor<br /> | **[[3unb]], [[3unf]] – m20S + inhibitor<br /> | ||
| - | **[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]] – y20S core+inhibitor<br /> | + | **[[3hye]], [[3gpj]], [[3dy3]], [[3dy4]], [[3e47]], [[3d29]], [[3bdm]], [[2zcy]], [[2gpl]], [[2fak]], [[2f16]], [[1jd2]], [[1g65]], [[3mg0]], [[3mg4]], [[3mg6]], [[3mg7]], [[3mg8]], [[3oeu]], [[3oev]], [[3okj]], [[3shj]], [[3un4]], [[3un8]], [[3sdi]], [[3sdk]], [[4fzc]], [[4fzg]], [[4gk7]], [[4eu2]], [[4inr]], [[4int]], [[4inu]], [[4jsq]], [[4jsu]], [[4jt0]], [[4qwx]], [[4qzz]], [[4r17]], [[4r18]], [[4rur]], [[5ahj]], [[4y69]], [[4y6v]], [[4y6z]], [[4y70]], [[4y74]], [[4y75]], [[4y77]], [[4y78]], [[4y7w]], [[4y7x]], [[4y7y]], [[4y80]], [[4y81]], [[4y82]], [[4y8g]], [[4y8h]], [[4y8i]], [[4y8j]], [[4y8k]], [[4y8l]], [[4y8m]], [[5dki]], [[5dkj]], [[5l52]], [[5l54]], [[5l55]], [[4y6a]], [[4y84]], [[4y8n]], [[4y8o]], [[4y8p]], [[4y8q]], [[4y8s]], [[4y8t]], [[4y8u]], [[4y9z]], [[4ya0]], [[4ya2]], [[4ya3]], [[4ya5]], [[4ya7]], [[4ya9]], [[5jhr]], [[5jhs]], [[5lai]], [[4r02]], [[2zcy]], [[5bou]], [[5laj]], [[6gop]], [[6hwb]], [[6hwa]], [[6hw9]], [[6hw8]], [[6hw7]], [[6hw6]], [[6hw5]], [[6hw4]], [[6hw3]], [[6hw0]], [[6hvy]], [[6hvx]], [[6hvw]], [[6hvv]], [[6hvu]], [[6hvt]], [[6hvs]], [[6hvr]], [[6hva]], [[6hv7]], [[6hv5]], [[6hv4]], [[6hv3]], [[6huv]], [[6huu]], [[6huq]], [[6huc]], [[6hub]], [[6htr]], [[6htp]], [[6htd]], [[6htc]], [[6htb]], [[6h39]] – y20S core+inhibitor<br /> |
| - | **[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]] – y20S (mutant) + inhibitor<br /> | + | **[[4qxj]], [[4qz0]], [[4qz1]], [[4qz2]], [[4qz3]], [[4qz4]], [[4qz5]], [[4qz6]], [[4qz7]], [[4qzw]], [[4qzx]], [[4r00]], [[4r02]], [[5cgg]], [[5cgh]], [[5cgi]], [[5d0t]], [[5fgh]], [[6hwf]], [[6g8n]], [[6g8m]], [[6g7f]] – y20S (mutant) + inhibitor<br /> |
**[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br /> | **[[4hnp]], [[4hrc]], [[4hrd]], [[4lqi]], [[4ltc]], [[4q1s]] - y20S core + antibiotics<br /> | ||
**[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br /> | **[[4nnn]], [[4nnw]], [[4no1]], [[4no6]], [[4no8]], [[4no9]], [[4qby]], [[4qlq]], [[4qls]], [[4qlt]], [[4qlu]], [[4qlv]] - y20S core+ peptide inhibitor<br /> | ||
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**[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br /> | **[[3nzj]], [[3nzw]], [[3nzx]] - y20S + TMC-95A mimic ligand<br /> | ||
**[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br /> | **[[4qvl]], [[4qw4]], [[4z1l]], [[3tdd]], [[4j70]] – y20S + cancer drug<br /> | ||
| - | **[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[5d0z]], [[5d0x]], [[5d0v]], [[5d0s]], [[5cz5]], [[5bxn]] - y20S (mutant) + cancer drug<br /> | + | **[[4qvm]], [[4qvn]], [[4qvp]], [[4qvq]], [[4qvv]], [[4qvw]], [[4qvy]], [[4qw0]], [[4qw1]], [[4qw3]], [[4qw5]], [[4qw6]], [[4qw7]], [[4qwf]], [[4qwg]], [[4qwi]], [[4qwj]], [[4qwk]], [[4qwl]], [[4qwr]], [[4qws]], [[4qwu]], [[5cz8]], [[5cz9]], [[5fgd]], [[5fge]], [[5fgf]], [[5fgg]], [[5fgi]], [[5fhs]], [[5d0z]], [[5d0x]], [[5d0v]], [[5d0s]], [[5cz5]], [[5bxn]], [[6hwe]], [[6hwd]] - y20S (mutant) + cancer drug<br /> |
**[[4x6z]] - y20S + modulator<br /> | **[[4x6z]] - y20S + modulator<br /> | ||
**[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br /> | **[[5gjq]] - y20S + ubiquitin carboxyl hydrolase 14 + polyubiquitin<br /> | ||
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**[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br /> | **[[5fmg]] - Pf20S + inhibitor - ''Plasmodium falciparum'' - Cryo EM<br /> | ||
**[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br /> | **[[5trr]], [[5trs]], [[5try]], [[5ts0]], [[5tho]], [[5trg]] - Mt20S + peptide<br /> | ||
| + | **[[3h6f]], [[3h6i]], [[3hf9]], [[2fhh]], [[3krd]], [[6ode]], [[6ocz]], [[6ocw]] – Mt20S core+inhibitor<br /> | ||
| + | **[[6qm7]] – Lt20S + leishmania drug – Cryo EM<br /> | ||
* Proteasome partial 20S particle | * Proteasome partial 20S particle | ||
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**[[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br /> | **[[1uel]] - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR<br /> | ||
**[[1yx4]] - hPRTS subunit 4 – NMR<br /> | **[[1yx4]] - hPRTS subunit 4 – NMR<br /> | ||
| - | **[[1yx5]], [[1yx6]], [[2kde]], [[2kdf]] - hPRTS subunit 4+ubiquitin – NMR<br /> | + | **[[1yx5]], [[1yx6]], [[2kde]], [[2kdf]], [[6mun]] - hPRTS subunit 4+ubiquitin – NMR<br /> |
**[[2o95]], [[2o96]] - hPRTS subunit 7<br /> | **[[2o95]], [[2o96]] - hPRTS subunit 7<br /> | ||
**[[3kw6]] - hPRTS subunit 8<br /> | **[[3kw6]] - hPRTS subunit 8<br /> | ||
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**[[2z59]] - mPRTS subunit RPN13+ubiquitin<br /> | **[[2z59]] - mPRTS subunit RPN13+ubiquitin<br /> | ||
**[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br /> | **[[2x5n]] - PRTS subunit RPN10 VWA domain – fission yeast<br /> | ||
| - | **[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br /> | ||
**[[4ady]] - yPRTS subunit RPN2<br /> | **[[4ady]] - yPRTS subunit RPN2<br /> | ||
| + | **[[5zmr]] - yPRTS subunit RPN5 N terminal – NMR<br /> | ||
**[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br /> | **[[3vlf]] - yPRTS subunit 7 + DNA mismatch repair protein<br /> | ||
| + | **[[4o8x]], [[4o8y]], [[5w83]], [[4owp]] - yPRTS subunit RPN8 + RPN11<br /> | ||
| + | **[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br /> | ||
| + | **[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br /> | ||
**[[2mr3]] - yPRTS subunit RPN9 – NMR<br /> | **[[2mr3]] - yPRTS subunit RPN9 – NMR<br /> | ||
**[[2mqw]] - yPRTS subunit RPN9 N terminal – NMR<br /> | **[[2mqw]] - yPRTS subunit RPN9 N terminal – NMR<br /> | ||
**[[2mri]] - yPRTS subunit RPN9 C terminal – NMR<br /> | **[[2mri]] - yPRTS subunit RPN9 C terminal – NMR<br /> | ||
| + | **[[5ln1]] - yPRTS subunit RPN10 + polyubiquitin<br /> | ||
**[[4b0z]] - yPRTS subunit RPN12<br /> | **[[4b0z]] - yPRTS subunit RPN12<br /> | ||
**[[2z4d]] - yPRTS subunit RPN13<br /> | **[[2z4d]] - yPRTS subunit RPN13<br /> | ||
**[[3vl1]] - yPRTS subunit RPN14 (mutant)<br /> | **[[3vl1]] - yPRTS subunit RPN14 (mutant)<br /> | ||
| - | **[[4o8x]], [[4o8y]], [[5w83]], [[4owp]] - yPRTS subunit RPN8 + RPN11<br /> | ||
| - | **[[4ocl]], [[4ocm]], [[4ocn]] - yPRTS subunit RPN8 + RPN11 + nanobody<br /> | ||
| - | **[[5u4p]] - yPRTS subunit RPN8 + RPN11 + S31<br /> | ||
**[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br / | **[[3t5v]], [[5l3t]], [[5g5p]], [[4trq]] - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1<br / | ||
**[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br /> | **[[3txm]], [[3txn]] – PRTS subunit P42B – ''Drosophila melanogaster''<br /> | ||
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**[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br /> | **[[4g4s]] – yPRTS + proteasome assembly chaperon 1 & 2<br /> | ||
**[[5a5b]] - yPRTS + UBP6 - Cryo EM<br /> | **[[5a5b]] - yPRTS + UBP6 - Cryo EM<br /> | ||
| - | + | **[[6ef3]], [[6ef2]], [[6ef1]], [[6ef0]] – yPRTS + ubiquitin-L40 – Cryo EM<br /> | |
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:12, 28 November 2019
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3D Structures of Proteasome
Updated on 28-November-2019
References
- ↑ Saeki Y, Tanaka K. Assembly and function of the proteasome. Methods Mol Biol. 2012;832:315-37. doi: 10.1007/978-1-61779-474-2_22. PMID:22350895 doi:http://dx.doi.org/10.1007/978-1-61779-474-2_22
- ↑ Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996;65:801-47. PMID:8811196 doi:http://dx.doi.org/10.1146/annurev.bi.65.070196.004101
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman
