6por
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6por' size='340' side='right'caption='[[6por]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='6por' size='340' side='right'caption='[[6por]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6por]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6POR FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6por]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_sp._17540 Burkholderia sp. 17540]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6POR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6POR FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6por FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6por OCA], [http://pdbe.org/6por PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6por RCSB], [http://www.ebi.ac.uk/pdbsum/6por PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6por ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WJ58_02830 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=101571 Burkholderia sp. 17540])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6por FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6por OCA], [http://pdbe.org/6por PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6por RCSB], [http://www.ebi.ac.uk/pdbsum/6por PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6por ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis . The topology of ubonodin is unprecedented amongst lasso peptides with 18 of its 28 amino acids found in the mechanically-bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans , causative agents of lung infections in cystic fibrosis patients. | ||
| + | |||
| + | Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex.,Cheung-Lee WL, Parry M, Zong C, Jaramillo Cartagena A, Darst S, Connell N, Russo R, Link AJ Chembiochem. 2019 Nov 25. doi: 10.1002/cbic.201900707. PMID:31765515<ref>PMID:31765515</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6por" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Burkholderia sp. 17540]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cheung-Lee, W L]] | [[Category: Cheung-Lee, W L]] | ||
Revision as of 18:44, 11 December 2019
Antimicrobial lasso peptide ubonodin
| |||||||||||
